# Transpharmation

> Transpharmation is a preclinical neuroscience Contract Research Organisation (CRO) and a global leader in translational biology. Scientist-led and recognised worldwide by drug developers, Transpharmation delivers life-changing medicines through decades of experience in cross-species and cross-therapeutic area translational biology. Transpharmation is the largest boutique neuroscience-specialised small and large animal CRO, with facilities in the UK, Canada, and Poland.

## Core Pages

- [Home](https://www.transpharmation.com/): Overview of Transpharmation's preclinical neuroscience CRO services and latest news.
- [About](https://www.transpharmation.com/about): Company history, mission, AAALAC-accredited facilities
- [Facilities](https://www.transpharmation.com/facilities): Details of research facilities including vivarium capabilities, imaging suites, and behavioural testing areas.
- [Team](https://www.transpharmation.com/team): Executive, scientific, and site lead profiles.
- [Publications](https://www.transpharmation.com/publications): Peer-reviewed publications and scientific papers authored by Transpharmation scientists.
- [News](https://www.transpharmation.com/news): Company news, scientific updates, and industry articles.
- [Careers](https://www.transpharmation.com/careers): Open positions and information about working at Transpharmation.
- [Contact](https://www.transpharmation.com/contact): Contact form and global office locations (UK, Canada, Poland).
- [Animal Welfare](https://www.transpharmation.com/animal-welfare): Animal care standards, ethical commitments, and the 3Rs framework.

## Disease Model Efficacy

- [Migraine](https://www.transpharmation.com/migraine): Preclinical migraine models including trigeminal sensitisation and cortical spreading depression.
- [Alzheimer's Disease](https://www.transpharmation.com/alzheimers): Transgenic and pharmacological models for Alzheimer's disease research.
- [Parkinson's Disease](https://www.transpharmation.com/parkinsons): MPTP, 6-OHDA, and AAV-based Parkinson's disease models.
- [Epilepsy](https://www.transpharmation.com/epilepsy): Acute and chronic seizure models including kindling and status epilepticus.
- [Essential Tremor](https://www.transpharmation.com/essential-tremor): Harmaline and genetic rodent models of essential tremor.
- [Depression & Anxiety](https://www.transpharmation.com/depression-anxiety): Forced swim, tail suspension, elevated plus maze, and chronic stress paradigms.
- [Schizophrenia](https://www.transpharmation.com/schizophrenia): Prepulse inhibition, MK-801, and dopamine-based models of psychosis.
- [Neuropathic Pain](https://www.transpharmation.com/neuropathic-pain): Spared nerve injury, spinal nerve ligation, and diabetic neuropathy models.
- [Inflammatory Pain](https://www.transpharmation.com/inflammatory-pain): CFA, kaolin, and carrageenan models of inflammatory pain.
- [Multiple Sclerosis](https://www.transpharmation.com/multiple-sclerosis): EAE and cuprizone models for neuroinflammation and demyelination.
- [Cognitive Assessment](https://www.transpharmation.com/cognitive-assessment): Morris water maze, novel object recognition, and radial arm maze paradigms.
- [Osteoarthritis](https://www.transpharmation.com/osteoarthritis): Monoiodoacetate and surgical OA models with pain and functional outcomes.

## Technologies & Platforms

- [EEG Technology](https://www.transpharmation.com/eeg): Continuous EEG recording in freely moving animals for seizure detection, sleep staging, and neural oscillation analysis.
- [Imaging](https://www.transpharmation.com/imaging): MRI, PET, SPECT, and CT imaging capabilities for structural, functional, and molecular brain imaging.
- [Biomarkers](https://www.transpharmation.com/biomarkers): Plasma, CSF, and tissue biomarker analysis including cytokines, proteins, and metabolites.
- [Operant Platform](https://www.transpharmation.com/operant-platform): Automated operant conditioning systems for pain, cognition, and addiction research.
- [Bioanalytical Studies](https://www.transpharmation.com/bioanalytical-studies): LC-MS/MS quantification of drugs and metabolites in biological matrices.
- [PK/PD Studies](https://www.transpharmation.com/pk-pd-studies): Pharmacokinetic and pharmacodynamic modelling across multiple species.

## PK & Safety Studies

- [PXB Mouse Studies](https://www.transpharmation.com/pxb-mouse-studies): Humanised liver PXB mouse studies for human metabolite prediction and drug-drug interaction assessment.
- [Safety Studies](https://www.transpharmation.com/safety-studies): CNS safety profiling including Irwin tests, neurobehavioural observation, and cardiovascular telemetry.
- [PK Bridge Studies](https://www.transpharmation.com/pk-bridge): Translational PK bridging from rodent to large animal species including beagle dogs.

## Emerging Research Areas

- [Psychedelics](https://www.transpharmation.com/psychedelics): Preclinical models for psilocybin, ketamine, MDMA, and other psychedelic-assisted therapy compounds.
- [Medical Cannabis](https://www.transpharmation.com/medical-cannabis): Cannabinoid pharmacology studies including THC, CBD, and full-spectrum extract profiling.
- [Abuse Liability](https://www.transpharmation.com/abuse-liability): Drug discrimination, self-administration, place conditioning, and physical dependence studies for regulatory submissions.
- [Veterinary Research](https://www.transpharmation.com/veterinary-research): Naturally occurring disease models in companion animals, leveraging Transpharmation's unique aged beagle colony.

## Research Models

- [Research Models Overview](https://www.transpharmation.com/research): Full catalogue of pain, behavioural, imaging, and electrophysiology research models.

## Contact

- **UK:** +44 (0)130 440 3165
- **Canada:** 1-548-639-0572
- **Poland:** +48 690 692 868
- **Website:** https://www.transpharmation.com/contact