Identifying robust and sensitive biomarkers during preclinical discovery can help to predict drug efficacy and improve clinical translation. The generation of consistent and translatable biomarker data through all stages of the drug discovery and development process reduces project risk and helps decision making. Moreover, profiling established clinical biomarkers in cellular and animal models can be used to confirm the translational relevance of preclinical research.

Our molecular biomarker services can be linked to any of our in vitro assays or in vivo models and our team of experts are available to assist you in designing bespoke protocols to achieve your objectives. Partnerships with biobanks and clinical research centres provides access to tissue, fluids, and clinical histories to assist clinical biomarker discovery.

Our biomarker capabilities enable us to:

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    Explore the mechanism of action of novel agents
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    Create bespoke biomarker-based bioassays to evaluate the biological activity and potency of novel compounds
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    Evaluate the impact of drug candidates on translatable biomarkers generated in disease models, adding to and strengthening traditional endpoint data
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    Investigate the impact of drug candidates on biomarkers associated with side-effect liability
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    Assist clinical biomarker translation from preclinical studies through partnerships with biobanks and clinical research centres, which provide access to tissue, fluids, and clinical histories

Cutting-edge and high-performance electrochemiluminescence (MESO SCALE DISCOVERY - MESO® QuickPlex SQ 120) technology facilitates the detection of proteins and phosphoproteins in rodent, canine, non-human primate, and human samples. Our imaging technologies include quantitative magnetic resonance (QMR) as well as light, fluorescent and confocal microscopy, which support histological techniques including immunohistochemistry (IHC), immunofluorescence and immunocytochemistry (ICC). Additional biomarker technologies we offer are standard ELISAs, flow cytometry and RT-qPCR.

All our protocols can be customised to detect your proteins of interest.