Patients with schizophrenia exhibit disturbances in information processing and cognitive impairment. These disturbances are clinically investigated with different paradigms of auditory event related potentials (ERP) as well as by appropriate cognitive tests aligned to specific cognitive domains, recommended by MATRICS, CNTRIS and TURNS initiatives, which can be recapitulated in rodents.

Our elegant electrophysiological approach enables detection of translational ERP endpoints such as N1 and MMN-like responses in standard and oddball paradigm stimuli in response to test compounds, benchmarked against NMDA antagonists, (ketamine, MK-801, PCP). Furthermore, our battery of rodent cognition tests provides the opportunity for assessing whether NCEs have the potential utility for treating a range of cognitive impairments associated with schizophrenia compared to atypical antipsychotics such as clozapine.

We also offer ‘classical models’ of positive symptoms, e.g amphetamine-evoked behaviour, using our advanced LABORAS home cage monitoring system.

Disease relevant models we offer include the following:

  • Aggression Screening Model

  • This test of recognition memory is based on the tendency of rodents to preferentially explore a novel compared to a familiar object. Test subjects are exposed to a sample stimulus (object), and after a delay of minutes to hours, are presented with the sample object together with a novel object. Memory of the familiar object is gauged by a time difference score spent exploring each object.

    Validation Data: Age-dependent impairment in learning and memory assessed by the novel object recognition task.
    Novel Object Recognition bar chart

    Aged rats show a decline in novel object recognition at 3h post sample stage, unlike young controls. Both young and aged rats show decline at 24h post sample stage.

  • Reversal learning
  • Reversal of amphetamine/PCP-induced behaviours using LABORAS