Humanized Models
Selecting preclinical models that reflect human biology is critical for confident decision-making in drug development. Our Humanized Models platform provides access to the PXB-Mouse®, a commercially advanced human liver chimeric model that supports the evaluation of liver-targeted therapies, drug metabolism, pharmacokinetics, safety, and toxicology through the use of functional human liver tissue.
Detail of offering
The PXB-Mouse® is an extensively published Mu/Hu Liver Chimeric model used across drug development programs, particularly in liver disease research as well as DMPK and toxicology studies. Using a unique hepatocyte replacement approach, PXB-Mice® develop functional human liver tissue that secretes human albumin and exhibits human-type bile profiles. Standard studies typically achieve average liver replacement indices of 80 to 85%.
The model demonstrates human-relevant liver function through the expression of more than 95% of mRNAs found in normal human liver tissue, alongside the expression of key human metabolic enzymes and transporters. This provides researchers with a platform for investigating drug metabolism, disposition, and liver-specific biological responses in a setting that closely reflects human hepatic function.
PXB-Mouse® study applications include drug metabolism, pharmacokinetic and safety assessment, viral hepatitis research, non-alcoholic steatohepatitis (NASH), and emerging approaches such as gene editing. Complementary in vitro studies can be performed using PXB-Cells®, enabling translation between in vitro and in vivo datasets through the use of the same human hepatocytes.
Applicable Portfolio Services
Have a program in mind?
To discuss how the PXB-Mouse® could support your drug development program, contact our team to explore the most appropriate study design for your research objectives.