Periodontal Disease
Dental disease is one of the most common health conditions affecting companion animals, with periodontal disease developing naturally through the accumulation of plaque and calculus over time. Transpharmation provides translational canine dental and oral health research capabilities that support the evaluation of therapeutics, nutritional products, dental devices, and preventative interventions using clinically relevant disease models.
Detail of offering
Transpharmation has extensive experience in the assessment of naturally occurring periodontal disease in dogs. Studies can be designed to evaluate both disease prevention and disease progression using either clean-mouth or dirty-mouth models. Dental procedures and assessments are performed to enable comprehensive evaluation of oral health status.
A range of clinical measures can be incorporated into studies, including:
- Periodontal disease staging
- Pocket depth measurements
- Gingival index assessments
- Gum health evaluations
- Gingival recession scoring
- Furcation and tooth mobility assessments
- Halitosis scoring and volatile sulfur compound measurement
These endpoints provide a comprehensive evaluation of disease severity and treatment response.
Studies can include quantitative assessment of plaque accumulation and calculus formation through established grading systems and plaque-disclosing techniques. These measures support the evaluation of products designed to improve oral hygiene and periodontal health.
Biological samples can be collected to investigate disease biomarkers and treatment responses. Available sample types include saliva, gingival crevicular fluid, subgingival plaque, buccal cells, blood, and other relevant biofluids. Analyses may include assessments of bacterial burden, inflammatory markers, and host response to treatment.
Dental studies can be supported by:
- Dental radiography
- High-quality oral photography
- Clinical oral examinations
These tools help characterize disease progression and document treatment outcomes.
Our canine periodontal disease models support the evaluation of a wide range of oral health interventions, including:
- Dental chews
- Functional foods
- Nutritional supplements
- Mechanical oral care products
- Dental implants
Studies can be tailored to meet specific research objectives and product development strategies.
Platforms used
Electroencephalography (EEG) In-vivo rodent telemetry
Imaging Services Companion animal imaging
Operant Platform Motivation, impulsivity, attention, cognition, memory
PK/PD Studies Endpoints for lead optimization
PK-Bridge PK studies for discovery budgets
Cognitive Assessment Aged-dog memory and cognitive decline
Have a program in mind?
Whether you are developing a therapeutic, nutritional intervention, dental device, or preventative oral healthcare product, our team can help design a study that generates meaningful translational data. Contact us to discuss your dental and oral health research requirements.