Mixed Pain (Fibromyalgia)
Fibromyalgia is a chronic, centrally mediated pain syndrome characterized by widespread hyperalgesia and allodynia without discrete peripheral nerve or tissue injury, reflecting dysfunction in central pain modulatory pathways, particularly monoaminergic (serotonin/norepinephrine) descending control.
Transpharmation offers the reserpine-induced myalgia model, in which pharmacological depletion of monoamines reproduces this diffuse, centrally driven hypersensitivity, providing a translationally relevant paradigm for evaluating compounds targeting central pain sensitization and monoaminergic pathways.
Models
Reserpine model,
Platforms used
Molecular Biomarkers & Histology Molecular biomarkers and tissue biomarker expression
Electroencephalography (EEG) In-vivo rodent telemetry
MoSeq AI-powered motion sequencing
Operant Platform Motivation, impulsivity, attention, cognition, memory
PK/PD Studies Endpoints for lead optimization
PK-Bridge PK studies for discovery budgets
Humanized Models PXB humanized-liver mice
SPIDAR Rapid analgesic screening
Transgenics Genetically modified mice
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Talk to a Transpharmation researcher about your study design and timelines.