Postoperative Pain
Postoperative pain (POP) is defined as a transient but extremely strong activation of the nociceptive network. Mechanical hypersensitivity is observed by applying force directly on the surgical wounds of patients after inguinal herniorrhaphy, open cholecystectomy or abdominal hysterectomy.
Models
Post-surgical/incisional pain (Brennan model),
Postoperative pain is a common surgical complication that can delay recovery, increase infection risk, and, in around 10% of patients, transition into persistent pain with neuropathic features. Nociceptive behavior is typically assessed using von Frey filaments, with paw withdrawal thresholds markedly and reproducibly reduced following incision. Considered the gold-standard preclinical model for postoperative pain, the Brennan model responds to clinically used analgesics such as morphine, ketorolac, and gabapentin, and is widely used to characterize the mechanisms of surgery-induced mechanical sensitization and to evaluate the potency of novel analgesic candidates in a model of postoperative pain (POP).
Read the full description: Post-surgical/incisional pain (Brennan model)
Platforms used
Molecular Biomarkers & Histology Molecular biomarkers and tissue biomarker expression
Electroencephalography (EEG) In-vivo rodent telemetry
MoSeq AI-powered motion sequencing
Operant Platform Motivation, impulsivity, attention, cognition, memory
PK/PD Studies Endpoints for lead optimization
PK-Bridge PK studies for discovery budgets
Humanized Models PXB humanized-liver mice
SPIDAR Rapid analgesic screening
Transgenics Genetically modified mice
Have a program in mind?
Talk to a Transpharmation researcher about your study design and timelines.