Dermatology
Canine atopic dermatitis is a chronic, relapsing inflammatory skin disease affecting up to 15% of the dog population, mirroring many aspects of human atopic dermatitis. Characterized by pruritus (itchiness), erythema, and recurrent skin infections, this condition significantly impacts the quality of life of both dogs and their owners.
Transpharmation offers two distinct models to support the development of dermatological therapeutics: a naturally occurring model of canine atopic dermatitis and an induced interleukin-31 (IL-31) pruritus model. These models enable the assessment of both long-term disease-modifying therapies and rapid-acting antipruritic agents.
Examples of endpoints:
- Pruritic behavior activity scoring
- CADESI scoring
- Skin photographs
- Inflammatory biomarkers
Platforms used
Electroencephalography (EEG) In-vivo rodent telemetry
Imaging Services Companion animal imaging
Operant Platform Motivation, impulsivity, attention, cognition, memory
PK/PD Studies Endpoints for lead optimization
PK-Bridge PK studies for discovery budgets
Cognitive Assessment Aged-dog memory and cognitive decline
Have a program in mind?
Talk to a Transpharmation researcher about your study design and timelines.