Diabetes
Diabetes presents complex challenges in glucose regulation and insulin management, requiring translational models that provide clinically relevant physiological and biomarker data. Transpharmation offers canine diabetes research capabilities that support the evaluation of insulin therapies, glucose management strategies, and novel anti-diabetic interventions.
Detail of offering
Transpharmation offers a well-characterized canine diabetes model with reduced endogenous insulin production, supporting the evaluation of diabetes therapeutics. Studies can also be conducted in healthy, non-diabetic dogs to support pharmacokinetic and pharmacodynamic assessments of investigational compounds.
A range of diabetes-relevant clinical endpoints can be incorporated into studies, including:
- Veterinary examinations
- Body weight and body condition scoring
- Food consumption and water intake
- Polyuria assessment through urine output monitoring
- Activity measurements
- Blood pressure, heart rate, and respiratory rate assessments
These measures provide insight into disease progression, treatment response, and overall animal health.
Studies can incorporate comprehensive metabolic monitoring, including:
- Blood glucose assessment
- Continuous interstitial fluid (ISF) glucose monitoring
- Insulin response measurements
- Serum fructosamine
- Ketone analysis
- Clinical biochemistry
- Hematology
- Urinalysis
These endpoints support evaluation of glycemic control, insulin activity, and overall diabetic status.
Oral and intravenous glucose tolerance testing (OGTT and IVGTT) can be used to characterize glucose handling and insulin dynamics. These assessments provide valuable information on treatment effects and glucose metabolism following intervention.
Platforms used
Electroencephalography (EEG) In-vivo rodent telemetry
Imaging Services Companion animal imaging
Operant Platform Motivation, impulsivity, attention, cognition, memory
PK/PD Studies Endpoints for lead optimization
PK-Bridge PK studies for discovery budgets
Cognitive Assessment Aged-dog memory and cognitive decline
Have a program in mind?
Successful diabetes programs depend on access to robust models and meaningful measures of glycemic control. Our team can help identify the most appropriate assessments and study design to support the evaluation of insulin products, glucose-monitoring technologies, and emerging anti-diabetic therapies.