Molecular Biomarkers & Histology
Biomarkers play a critical role in understanding disease mechanisms and supporting the development of translational models. At Transpharmation, we combine advanced protein biomarker analysis with well-characterized preclinical disease models to generate clinically relevant insights into disease progression and therapeutic efficacy.
Detail of offering
The success of any biomarker program depends on selecting the right analytical tools to answer the right biological questions. Our platform combines established and advanced research methodologies to support biomarker discovery, validation, and translational studies across a broad range of therapeutic areas. Explore the techniques below to learn how our capabilities can support your specific research objectives.
A highly sensitive immunoassay platform based on electrochemiluminescence detection. MSD enables the simultaneous quantification of multiple biomarkers in a single sample, making it ideal for translational and preclinical research.
MSD Meso QuickPlex SQ 120MM: ultra-sensitive electrochemiluminescence multiplex assays.
A widely used immunoassay technique for the quantitative measurement of specific proteins, cytokines, and biomarkers in biological samples. ELISA is reliable, robust, and commonly applied in drug discovery and biomarker studies.
A protein analysis method used to detect and semi-quantify specific target proteins. Western blotting provides information on protein expression and molecular weight, supporting target validation and mechanism-of-action studies.
Moreover, our expanded scientific capabilities are powered by our collaboration with In-Life Institute of Animal Reproduction and Food Research PAS Olsztyn. Together, we are opening new avenues for high-precision research and advanced analytical workflows:
- Tissue fixation, processing, paraffin embedding, and preparation of paraffin or frozen sections
- Histochemical and immunohistochemical (IHC) staining
- Microscopic imaging and analysis of tissue sections
- Cell proliferation and cell-cycle profiling
- Apoptosis detection (Annexin V)
- High-precision sorting of labeled cells and molecules
- High-resolution 3D imaging
- Time-lapse imaging for dynamic cellular processes
- Cell clone isolation and immortalization
- Lipotransfection, electroporation, and vector transfection
- Quantification of metabolites in biological fluids and tissues
- Metabolic biomarker profiling
- Bioavailability and pharmacokinetic studies
- HPLC and micro-UHPLC gradient systems with autosamplers for high-resolution chemical analysis
Key biomarker panels
- NfL
- Aβ42/Aβ40
- GFAP
- pTAU (Thr231)/Total TAU
- S100B
- MBP
- IL-1β
- IL-2
- IL-6
- IL-10
- IL-17A/F
- TNF-α
- IFN-γ
- MCP-1 (CCL2)
- KC/GRO (CXCL1)
- MIG (CXCL9)
- IP-10 (CXCL10)
- MIP-1α (CCL3)
- MIP-1β (CCL4)
- CRP
- Corticosterone
- BDNF
- PSD-95
- Synaptophysin
Metabolic markers
- Glucose (fasting & non-fasting)
- Insulin
- C-peptide
- GLP-1
- Leptin
- Peptide YY
- FGF21
Lipid metabolism
- Total cholesterol
- LDL cholesterol
- HDL cholesterol
- Triglycerides (TG)
- ApoB
Organ function & tissue damage
- ALT
- AST
- LDH
- Creatine Kinase (CK)
- Alpha-Amylase
- Lipase DGGR
Metabolic inflammation
- IL-6
- TNF-α
- MCP-1
- KC/GRO
- MIP-1α
- MIP-1β
- IL-1β
- IL-6
- IL-10
- TNF-α
- IFN-γ
- MCP-1
- KC/GRO
- CTX-II
Models
Applicable Portfolio Services
Have a program in mind?
Talk to a Transpharmation researcher about your study design and timelines.