Metabolic Disorders Biomarkers

Successful metabolic disease research relies on robust biomarkers that reflect physiological, biochemical, and inflammatory changes. By combining established analytical approaches with ongoing assay development, we help researchers generate actionable data tailored to their specific scientific goals.

Mouse model of obesity – DIO (diet-induced obesity)

Bar charts of serum triglycerides (TGA) and cholesterol (mmol/L) in female and male mice for control + vehicle, DIO + vehicle and DIO + semaglutide: higher in DIO mice and lower with semaglutide.
Bar charts of serum KC/GRO (female and male), MCP-1 and TNF-α (pg/mL) for control + vehicle, DIO + vehicle and DIO + semaglutide: higher in DIO mice and lower with semaglutide.

The graphs showing KC/GRO, MCP-1, TNF-α, triglycerides (TG) and cholesterol expression indicate elevated levels of these biomarkers in the serum of obese animals (high-fat diet) compared to control animals and animals treated with semaglutide (Sema).

Key biomarker panels

Metabolic markers

  • Glucose (fasting & non-fasting)
  • Insulin
  • C-peptide
  • GLP-1
  • Leptin
  • Peptide YY
  • FGF21

Lipid metabolism

  • Total cholesterol
  • LDL cholesterol
  • HDL cholesterol
  • Triglycerides (TG)
  • ApoB

Organ function & tissue damage

  • ALT
  • AST
  • LDH
  • Creatine Kinase (CK)
  • Alpha-Amylase
  • Lipase DGGR

Metabolic inflammation

  • IL-6
  • TNF-α
  • MCP-1
  • KC/GRO
  • MIP-1α
  • MIP-1β