Models & Assays
Feeding Induced by Palatability or Deprivation
Rats are trained either to consume their daily food ration over a specific time period each day, i.e. feeding induced by deprivation, or given access to a sweetened diet in a specific location and time each day without restriction to standard food, i.e feeding induced by palatability. Enables the administration of an NCE to be precisely timed to feeding.
Validation Data: Effect of lorcaserin (Belviq) on feeding induced by palatability or deprivation
Percentage change in food intake following lorcaserin (0.3-3 mg/kg SC) compared to vehicle pretreatment in rats trained to consume food over a limited access period under conditions of 22h food deprivation, or palatability-induced feeding in non-deprived rats. Data modified from: Higgins et al (2012) Neuropsychopharmacology 37: 1177-1191.