PK-Bridge
Pharmacokinetic studies bridge the gap between compound activity and therapeutic success. By providing a detailed understanding of how the body processes the drug (absorption, distribution, metabolism, excretion), PK data enables smarter decisions, reduces development risk, and increases the likelihood of advancing successful drug candidates into the clinic. At Transpharmation we offer rapid turnaround of a wide range of bespoke rat, mouse and dog pharmacokinetic protocols. All protocols are tailored to client requirements helping you generate datasets for lead optimization and candidate progression decisions.
Our oral and intravenous pharmacokinetic studies provide essential insight into bioavailability, Cmax, half-life, clearance and target tissue exposure, helping you make informed decisions on dose selection and route of administration.
Detail of offering
- Species
- Rat
- Mouse
- Dog
- Routes of administration
- Oral
- Intravenous (bolus or infusion)
- Subcutaneous
- Intraperitoneal
- Intramuscular
- Intranasal
- Intratracheal
- Intracolonic
- Sampling methods
- Terminal sampling
- Serial sampling via jugular vein cannulation or venipuncture
- Bile duct cannulated animal studies
- Sample types
- Blood
- Plasma
- Serum
- Bile
- Excreta: feces and urine
- Cerebrospinal fluid (CSF)
- Tissues, including brain regions, intestine, lymph nodes and liver
- Study types
- Formulation support
- Tolerability studies
- Dose range finding
- Single-dose or multiple-dose studies
- Discrete or cassette dosing
- Cannulated and non-cannulated animal studies
- Metabolic cage studies
- Bioanalysis partnerships
- LC-MS/MS method development and qualification for test articles
- Processing and analysis of study samples
- Pharmacokinetic analysis and standardized reporting, including WinNonlin outputs
- Global sample shipment
Applicable Portfolio Services
Have a program in mind?
From early screening through to candidate selection, our experienced scientists provide tailored PK solutions designed to answer critical development questions and reduce project risk. Contact Transpharmation today to discuss your PK study requirements and discover how we can support your development program.