Models & Assays
Behavioural Satiety Sequence
Typically rats given access to food will display a sequence of behaviours as they feed to satiation, i.e feed>active/groom>rest. Provides the means to study effect of an NCE on this behavioural sequence to measure specificity of any anorectic effect.
Effect of lorcaserin (1 mg/kg) on the behavioural satiety sequence measured during the palatability-induced feeding experiment. Note in the vehicle controls and lorcaserin (1 mg/kg) groups, the predominant behaviours are feeding and active/grooming over the first 15-20min, before ‘inactive’ predominates from 20-25 min onwards. At this dose, lorcaserin is therefore reducing food intake with minimal effect on the behavioural satiety sequence. Data modified from: Higgins et al (2012) Neuropsychopharmacology 37: 1177-1191.