Models & Assays
EEG
Discover the power of EEG recording as a valuable, translational tool for characterization of sleep, mood disorders, and more.
Since similar EEG readouts can be made from both rodents and human patients, EEG serves as a highly translational tool in preclinical drug discovery. Many currently marketed drugs have clear dose and time-dependent effects on specific EEG frequency bands, which can serve as pharmacodynamic biomarkers for target engagement, efficacy and tolerability. Our services include studying potential antidepressants’ and sleep modulators’ effects on rodents EEG through novel DSI technology of wireless bipotential telemetry. Transpharmation’s recent findings demonstrate the effect of sleep-inducing zolpidem (10 & 30 mg/kg) and anti narcoleptic modafinil (100 & 300 mg/kg) as well as ketamine (5 & 10 mg/kg) and psilocybin (3 & 10 mg/kg) on sleep and EEG in male C57BL/6 mice.
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- Leiser SC, Dunlop J, Bowlby MR, Devilbiss DM. Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research. Biochem Pharmacol. 2011 Jun 15;81(12):1408-21.
- Yener GG, Başar E. Brain oscillations as biomarkers in neuropsychiatric disorders: following an interactive panel discussion and synopsis. Suppl Clin Neurophysiol. 2013;62:343-63.