Models & Assays

Disease Model Efficacy PK & Safety Aged Beagle Model

Pain & Itch

  • Capsaicin
  • Chemotherapy-induced Peripheral Neuropathy
  • Painful Diabetic Neuropathy
  • Formalin Test
  • Freund’s Complete Adjuvant Model of Inflammation
  • Post-Operative Pain
  • Compound 48/80-Induced Itch Test
  • Nerve Ligation Models
  • Spared Nerve Injury Model of Neuropathic Pain
  • Tail Flick Test

Epilepsy

  • Electrically Induced Acute Seizures
  • Amygdala Kindling
  • Transgenic Mice

Obesity

  • Acute Feeding Tests
  • Behavioural Satiety Sequence
  • Chronic Obesity Models
  • Feeding Induced by Palatability or Deprivation
  • Evaluation of Malaise
  • Operant Based Tests

Addiction

In addition to providing a platform to study the potential for an NCE to reduce a specific aspect of a drug, known to contribute to its liability for abuse, i.e. efficacy based study, these same tests may be applied to investigate abuse potential of an NCE, i.e safety based study. Transpharmation has experience in either approaches to study an NCE.
  • Drug Discrimination
  • Drug Dependence
  • Locomotor Activity
  • Place Conditioning
  • Drug Self-administration

Parkinson's Disease

  • Rotenone Model

Essential Tremor

  • Tremor Plate
  • Harmaline-Induced Tremor

Alzheimer's Disease

  • Amyloid Hypothesis

Cognition

Transpharmation offers a capability for assessment of NCEs in rodent and canine tests of cognition, providing an opportunity to identify efficacy for therapeutic indications associated with a cognitive disorder, and to support safety assessment of novel NCEs. Multiple tests are selected to offer a broad analysis of drug effects against distinct cognitive domains. Various means to challenge cognitive function are available, from natural (aging, task manipulation) to pharmacological. Some of these tests have direct human equivalents offering translational approaches to studying NCEs.
  • Cognitive Selectivity
  • Executive Function (Reversal Learning)
  • 5-Choice Serial Reaction Time Task
  • Morris Water Maze
  • Multiple Cognitive Domain Testing
  • Novel Object Recognition Test
  • Operant Platform
  • Selective Attention (Visual Search Task)
  • Visuospatial Complex Learning and Short-term Memory

Anxiety, Depression & Fatigue

  • Chronic Social Defeat
  • Elevated Zero Maze
  • Forced Swim Test
  • Open Field
  • Tail Suspension Test

Schizophrenia & Autism

  • Aggression Screening Model
  • Mismatch-negativity (MMN)