Models & Assays
Pain & Itch
Epilepsy
- Electrically Induced Acute Seizures
- Amygdala Kindling
- Transgenic Mice
Obesity
Addiction
In addition to providing a platform to study the potential for an
NCE to reduce a specific aspect of a drug, known to contribute to
its liability for abuse, i.e. efficacy based study, these same
tests may be applied to investigate abuse potential of an NCE, i.e
safety based study. Transpharmation has experience in either
approaches to study an NCE.
Multiple Sclerosis
Parkinson's Disease
Essential Tremor
Alzheimer's Disease
Cognition
Transpharmation offers a capability for assessment of NCEs in
rodent and canine tests of cognition, providing an opportunity to
identify efficacy for therapeutic indications associated with a
cognitive disorder, and to support safety assessment of novel
NCEs. Multiple tests are selected to offer a broad analysis of
drug effects against distinct cognitive domains. Various means to
challenge cognitive function are available, from natural (aging,
task manipulation) to pharmacological. Some of these tests have
direct human equivalents offering translational approaches to
studying NCEs.
Anxiety, Depression & Fatigue
Schizophrenia & Autism
- Aggression Screening Model
- Mismatch-negativity (MMN)