Models & Assays
Pain & Itch
- Capsaicin
- Chemotherapy-induced Peripheral Neuropathy
- Painful Diabetic Neuropathy
- Formalin Test
- Freund’s Complete Adjuvant Model of Inflammation
- Post-Operative Pain
- Compound 48/80-Induced Itch Test
- Nerve Ligation Models
- Spared Nerve Injury Model of Neuropathic Pain
- Tail Flick Test
Epilepsy
- Electrically Induced Acute Seizures
- Amygdala Kindling
- Transgenic Mice
Obesity
- Acute Feeding Tests
- Behavioural Satiety Sequence
- Chronic Obesity Models
- Feeding Induced by Palatability or Deprivation
- Evaluation of Malaise
- Operant Based Tests
Addiction
In addition to providing a platform to study the potential for an
NCE to reduce a specific aspect of a drug, known to contribute to
its liability for abuse, i.e. efficacy based study, these same tests
may be applied to investigate abuse potential of an NCE, i.e safety
based study. Transpharmation has experience in either approaches to
study an NCE.
- Drug Discrimination
- Drug Dependence
- Locomotor Activity
- Place Conditioning
- Drug Self-administration
Parkinson's Disease
- Rotenone Model
Essential Tremor
- Tremor Plate
- Harmaline-Induced Tremor
Alzheimer's Disease
- Amyloid Hypothesis
Cognition
Transpharmation offers a capability for assessment of NCEs in rodent
and canine tests of cognition, providing an opportunity to identify
efficacy for therapeutic indications associated with a cognitive
disorder, and to support safety assessment of novel NCEs. Multiple
tests are selected to offer a broad analysis of drug effects against
distinct cognitive domains. Various means to challenge cognitive
function are available, from natural (aging, task manipulation) to
pharmacological. Some of these tests have direct human equivalents
offering translational approaches to studying NCEs.
- Cognitive Selectivity
- Executive Function (Reversal Learning)
- 5-Choice Serial Reaction Time Task
- Morris Water Maze
- Multiple Cognitive Domain Testing
- Novel Object Recognition Test
- Operant Platform
- Selective Attention (Visual Search Task)
- Visuospatial Complex Learning and Short-term Memory
Anxiety, Depression & Fatigue
- Chronic Social Defeat
- Elevated Zero Maze
- Forced Swim Test
- Open Field
- Tail Suspension Test
Schizophrenia & Autism
- Aggression Screening Model
- Mismatch-negativity (MMN)