Place conditioning assesses the motivational effects of compounds including reward and aversion. Safety studies examine the motivational effects of a novel compound, while efficacy studies assess the ability of a compound to modulate the rewarding and aversive effects of drugs of abuse.
Morphine
Data presented: Morphine elicits a conditioned place preference, increases locomotion, and elicits a conditioned increase in locomotion in the morphine-paired chamber in a drug-free state (n=8 Male Sprague-Dawley rats).
Heroin
Data presented: Heroin elicits a conditioned place preference, increases locomotion, and elicits a conditioned increase in locomotion in the heroin-paired chamber in a drug-free state (n=8 male Sprague-Dawley rats).
Nicotine
Data presented: Nicotine elevates locomotion and elicits a conditioned place preference (n=8 male Sprague-Dawley rats).
