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Models & Assays

Place Conditioning

Place conditioning assesses the motivational effects of compounds including reward and aversion. Safety studies examine the motivational effects of a novel compound, while efficacy studies assess the ability of a compound to modulate the rewarding and aversive effects of drugs of abuse.

Place conditioning chart showing morphine-induced conditioned place preference in rats — Data presented: Male Sprague-Dawley rats modulate their behaviour and intake depending on the intravenous dose per infusion they receive.

Place conditioning chart showing heroin-induced conditioned place preference and increased locomotion — Data presented: Heroin elicits a conditioned place preference, increases locomotion, and elicits a conditioned increase in locomotion in the heroin-paired chamber in a drug-free state (n=8 male Sprague-Dawley rats).

Place conditioning chart showing nicotine-induced elevated locomotion and place preference — Data presented: Nicotine elevates locomotion and elicits a conditioned place preference (n=8 male Sprague-Dawley rats).

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