Models & Assays

Transection of the tibial and peroneal branches of the sciatic nerve produces a long lasting neuropathy of the denervated paw, characterized by tactile and cold allodynia. These effects may be maintained for several weeks post surgery enabling long term chronic studies, and/or within subject test designs to be undertaken.

SNI and sham operated rats were surgically prepared. By 10 days all SNI lesioned animals developed tactile/cold allodynia relative to sham controls. Approximately 30 days post surgery the animals were treated with Carbamazepine (CBZ) 10-30mg/kg. Acute CBZ attenuated the cold allodynia, but not the tactile allodynia