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Models & Assays

Tremor Plate

A piezoelectric plate can be used to record tremor events in rats or mice (SR-LAB from San Diego Instruments). Various quantifiable data can be retrieved from a single recording (power spectrum, intensity, duration, time spent in tremor) to assess whether NCEs affect the number of tremors, the duration of tremors, and/or the intensity of tremors 2-6.

Graph depicting the number, duration and intensity of
    tremors, and/or the intensity of tremors

  1. Thanvi B, Lo N, Robinson T. Essential tremor-the most common movement disorder in older people. Age Ageing. 2006 Jul;35(4):344-9
  2. Martin FC, Thu Le A, Handforth A. Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. Mov Disord. 2005 Mar;20(3):298-305
  3. Pan MK, Ni CL, Wu YC, Li YS, Kuo SH. Animal Models of Tremor: Relevance to Human Tremor Disorders. Tremor Other Hyperkinet Mov (NY). 2018 Oct 9;8:587
  4. Ossowska K, Głowacka U, Kosmowska B, Wardas J. Apomorphine enhances harmaline-induced tremor in rats. Pharmacol Rep. 2015 Jun;67(3):435-41
  5. Paterson NE, Malekiani SA, Foreman MM, Olivier B, Hanania T. Pharmacological characterization of harmaline-induced tremor activity in mice. Eur J Pharmacol. 2009 Aug 15;616(1-3):73-80
  6. Kosmowska B, Wardas J, Głowacka U, Ananthan S, Ossowska K. Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats. CNS Neurosci Ther. 2016 Jan;22(1):53-62.

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