P301L Tau Mouse Model

The P301L Tau (JNPL3) transgenic mouse provides a model of progressive tau pathology, driven by expression of the human P301L mutation in the microtubule-associated protein tau gene (MAPT). The model demonstrates increased total and phosphorylated tau within the brain and increased NfL in plasma and CSF, supporting the assessment of tau-associated pathology and neurodegeneration.

Phosphorylated tau in the P301L Tau mouse brain
Bar charts of the pTau/Tau ratio in the cortex, cerebellum and hippocampus: higher in Tau P301L mice than in wild type in all three.

The results show an increase in the ratio of phosphorylated tau protein to total tau protein present in the brain structures of animals with a modified tau protein gene compared to wild-type animals.