Models & Assays

Disease Model Efficacy PK & Safety Aged Beagle Model

PK & Safety

  • Primary ICH S7A CNS Core Battery
  • Supplemental CNS Safety
  • Exploratory Toxicology
  • Drug-Drug Interaction Studies
  • Pharmacokinetics Studies

CNS Drug Disposition

  • Total Brain Tissue Collection, Plasma Collection, and Free Fraction Determination
  • Quantitative Microdialysis in Rats
  • Serial CSF Sampling in Beagle Dogs
  • Serial CSF and Plasma Sampling in Freely Moving Rats
  • Terminal CSF and Plasma Sampling in Mice