All papers and posters

Formoterol attenuates lipopolysaccharide-induced mnemonic impairment in the delayed nonmatch to position task in rats(PubMed, opens in new tab)

M. McAuslan, D. Kozareva, F. Dunphy-Doherty, M. Corrigan, J. Prenderville, J. Huxter, A. Harkin

Behavioural Pharmacology, 2026

Acute trazodone administration reduces behavioral and physiological indicators of travel-induced anxiety in dogs in a road travel model(DOI, opens in new tab)

Gary Landsberg, Jessica Mendes, Whitney Kosziwka, Deborah A. Keys, Andria Gordon, Andrew King, Joseph A. Araujo, Christina de Rivera

Sec. Animal Behavior and Welfare Volume 13 - 2026

Anxiety-related platform in zebrafish (Danio rerio) larvae: An integrated analysis of behavioural and molecular assay in drug screening research(PubMed, opens in new tab)

M. Potoczna, N. Kasica, M. Chmielewska-Krzesińska, J. Dybalska-Szczepanek, K. Wąsowicz, E. Sokołowska, P. Podlasz

Biomedicine & Pharmacotherapy, 2026

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1(PubMed, opens in new tab)

X. Zhang, P. H. Patra, J. Yang

The Journal of Physiology, 2026

Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter and immune cells in multiple sclerosis(PubMed, opens in new tab)

A. Otálora-Alcaraz, M. C. Sun, N. Hofman, L. Costelloe, H. Kearney, J. A. Prenderville, E. J. Downer

Multiple Sclerosis and Related Disorders, 2026

An examination of the interaction between the interoceptive and reinforcing properties of morphine: a self-administration study in male and female rats(PubMed, opens in new tab)

Allyson K Andrade, Briana Renda, Adiia P Stone, Michael Sharivker, Jessica M Karlovcec, Rita El Azali, Francesco Leri, Scott T Barrett, Jennifer E Murray

Springer Nature Link

The Canine Cognitive Dysfunction Syndrome Working Group guidelines for diagnosis and monitoring of canine cognitive dysfunction syndrome(PubMed, opens in new tab)

Natasha J. Olby; Joseph A. Araujo; Margaret E. Gruen; Phillipa Johnson; Eniko Kubinyi; Gary Landsberg; Caitlin S. Latimer; Stephanie McGrath; Brennen McKenzie; Julie A. Moreno; Monica Tarantino; Holger Volk

Journal of the American Veterinary Medical Association (JAVMA)

A comparative assessment of the antidepressant efficacy of ketamine, psilocybin, and fluoxetine in a chronic stress model(PubMed, opens in new tab)

Małgorzata Domżalska, Joanna Kwiatkowska, Iwona Cichoń, Ewa Sokołowska

Scientific Reports volume 15

Behavioral improvement in dystrophic mdx23 mouse following repeated antisense oligonucleotides injections(PubMed, opens in new tab)

A. Aghaeipour, M. Mitsogiannis, C. Fergus, K. Tetorou, T. Gileadi, E. Stojek, S. Talavera, S. Singh, M. Siddle, J. Prendeville, E. Sokolowska, V. Kelly, J. Morgan, F. Montanaro, F. Muntoni

Molecular Therapy: Nucleic Acids, 2025

Pharmacological characterisation of psilocybin and 5-MeO-DMT discriminative 41 cues in the rat and their translational value for identifying novel psychedelics(PubMed, opens in new tab)

Higgins GA, MacMillan C, de Lannoy I, Tyler C, Slassi M.

J Psychopharmacol. 2025 Aug 27:2698811251361453. doi: 10.1177/02698811251361453.

Gut Microbiota Variation in Aging Dogs with Osteoarthritis(PubMed, opens in new tab)

Fatemeh Balouei, Christina de Rivera, Andrea Paradis, Bruno Stefanon, Stephanie Kelly, Noelle McCarthy, Paolo Mongillo

Animals

Impact of distinct dystrophin gene mutations on behavioral phenotypes of Duchenne muscular dystrophy(PubMed, opens in new tab)

A. Saoudi, M. D. Mitsogiannis, F. Zarrouki, C. Fergus, E. Stojek, S. Talavera, D. Moore-Frederick, V. P. Kelly, A. Goyenvalle, F. Montanaro, F. Muntoni, J. A. Prenderville, E. Sokolowska, C. Vaillend

Disease Models & Mechanisms, 2024

The NLRP3 inflammasome: A central player in multiple sclerosis(PubMed, opens in new tab)

A. Otálora-Alcaraz, T. Reilly, N. Oró-Nolla, M. C. Sun, L. Costelloe, H. Kearney, P. H. Patra, E. J. Downer

Biochemical Pharmacology, 2025

The anxiogenic drug yohimbine is a reinforcer in male and female rats(PubMed, opens in new tab)

Briana Renda, Francesco Leri

Neuropsychopharmacology. 2024 Dec;50(2):432-443. doi: 10.1038/s41386-024-01985-1. Epub 2024 Sep 17.

The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy(PubMed, opens in new tab)

J. C. Richardson, G. A. Higgins, N. Upton, P. Massey, M. Cunningham, S. Wilson, J. Holenz, C. Taylor, A. Lavrov, H. Lin, Y. Matsuoka, A. J. Brown

Pharmacology Research & Perspectives, 2024

ART26.12, a novel fatty acid-binding protein 5 inhibitor, shows efficacy in multiple preclinical neuropathy models(PubMed, opens in new tab)

W. G. Warren, M. Osborn, A. David-Pereira, C. Tsantoulas, W. Xue, A. Yates, S. E. OSullivan

European Journal of Pain, 2025

Effect of a single psilocybin treatment on Fos protein expression in male rat brain(PubMed, opens in new tab)

Funk D, Araujo J, Slassi M, Lanthier J, Atkinson J, Feng D, Lau W, Lê A, Higgins GA.

Neuroscience . 2024 Feb 16:539:1-11. doi: 10.1016/j.neuroscience.2024.01.001. Epub 2024 Jan 4.

Procognitive and neurotrophic benefits of α5‑GABA‑A receptor positive allosteric modulation in a β‑amyloid deposition model of Alzheimer’s disease pathology(PubMed, opens in new tab)

Ashley M. Bernardo; Michael Marcotte; Kayla Wong; Dishary Sharmin; Kamal P. Pandey; James M. Cook; Etienne L. Sibille; Thomas D. Prevot

Alzheimer’s & Dementia

Ketamine suppresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression(PubMed, opens in new tab)

Sandor Kantor, Michael Lanigan, Lauren Giggins, Lisa Lione, Lilia Magomedova, Inés de Lannoy, Neil Upton, Mark Duxon

Behavioural Brain Research Volume 449, 9 July 2023, 114473

Effects of 5-HT2C receptor stimulation in male mice on behaviour and Fos expression: Feeding, reward and impulsivity(PubMed, opens in new tab)

Paul J Fletcher, Arya Rahbarnia, Zhaoxia Li, Xiaodong Ji, Guy A Higgins, Douglas Funk, A D Lê

Behavioural Brain Research. 2023 Jun 5:447:114438.

Refinements to rodent head fixation and fluid/food control for neuroscience(PubMed, opens in new tab)

Chris Barkus, Caroline Bergmann, Tiago Branco, Matteo Carandini, Paul T Chadderton, Gregorio L Galiñanes, Gary Gilmour, Daniel Huber, John R Huxter, Adil G Khan, Andrew J King, Miguel Maravall, Tina O'Mahony, C Ian Ragan, Emma S J Robinson, Andreas T Schaefer, Simon R Schultz, Frank Sengpiel, Mark J Prescott

Journal of Neuroscience Methods. 2022 Nov 1;381:109705.

Induction of type I diabetes mellitus in beagle dogs using alloxan and streptozotocin(PubMed, opens in new tab)

Araujo, J., Paradis, A., Mendes, J., Petrik, S., & de Rivera, C.

Current Protocols, 2, e580. doi: 10.1002/cpz1.580

HCN2 Ion Channels Drive Pain in Rodent Models of Migraine(PubMed, opens in new tab)

Christoforos Tsantoulas, Aidan Ng, Larissa Pinto, Anna P. Andreou and Peter A. McNaughton

J Neurosci. 2022 Oct 5;42(40):7513-7529. doi: 10.1523/JNEUROSCI.0721-22.2022. Epub 2022 Sep 2.

Effects of pimavanserin and lorcaserin on alcohol self-administration and reinstatement in male and female rats(PubMed, opens in new tab)

Paul J Fletcher, Zhaoxia Li, Xiaodong Ji, Guy A Higgins, Douglas Funk, A D Lê

Neuropharmacology. 2022 Sep 1;215:109150.

Sphingolipids and DHA Improve Cognitive Deficits in Aged Beagle Dogs(PubMed, opens in new tab)

Joseph A Araujo, Sergi Segarra, Jessica Mendes, Andrea Paradis, Melissa Brooks, Sandy Thevarkunnel, Norton W Milgram

Frontiers Veterinary Science. 2022 Jul 13;9:646451.

Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer's Disease in Rat and Dog (PubMed, opens in new tab)

Etienne Lessard , Kerry Rennie, Arsalan Haqqani, Binbing Ling , James Whitfield, Andrea Paradis, Joseph Araujo, Nathan Yoganathan, John Gillard, Danica Stanimirovic, Balu Chakravarthy

Pharmaceutical Research. 2022 Jul;39(7):1497-1507.

Evaluation of Recombinant Botulinum Neurotoxin Type A1 Efficacy in Peripheral Inflammatory Pain in Mice(PubMed, opens in new tab)

Beatrice Oehler, Cindy Périer, Vincent Martin, Amy Fisher, Stéphane Lezmi, Mikhail Kalinichev, Stephen B McMahon

Frontiers in Molecular Neuroscience. 2022 May 26;15:909835.

The Effects of Drug Treatments for ADHD in Measures of Cognitive Performance(PubMed, opens in new tab)

Guy A Higgins, Leo B Silenieks

Current Topics Behavioral Neurosciences. 2022;57:321-362.

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective(PubMed, opens in new tab)

John R Kelly, Claire M Gillan, Jack Prenderville, Clare Kelly, Andrew Harkin, Gerard Clarke, Veronica O'Keane

Frontiers Psychiatry. 2021 Dec 17;12:800072.

Measuring Amyloid-β Peptide Concentrations in Murine Brain with Improved ELISA Assay(PubMed, opens in new tab)

H Benson Peng, Inés A M de Lannoy, K Sandy Pang

Current Protocols. 2021 Oct

Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β-amyloid peptide accumulation in mice(PubMed, opens in new tab)

H Benson Peng, Paola Bukuroshi, Matthew R Durk, Paul Grootendorst, Xiaoyu Yan, Sophie R Pan, Ines A M de Lannoy, K Sandy Pang

Biopharm Drug Dispos. 2021 Sep;42(8):372-388.

Contrasting effects of d-amphetamine and atomoxetine on measures of impulsive action and choice(PubMed, opens in new tab)

Guy A Higgins, Matt Brown, Cam MacMillan, Leo B Silenieks, Sandy Thevarkunnel

Pharmacol Biochem Behav. 2021 Aug

Fracture-induced pain-like behaviours in a femoral fracture mouse model(PubMed, opens in new tab)

R Magnusdottir, S Gohin, F Ter Heegde, M Hopkinson, I F McNally , A Fisher, N Upton, A Billinton, C Chenu

Osteoporosis International. 2021 Nov;32(11):2347-2359.

Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats(PubMed, opens in new tab)

B Garrone, L Durando, J Prenderville, E Sokolowska, C Milanese, F P Di Giorgio, C Callaghan, M Bianchi

Sci Rep. 2021 May 12;11(1):10139.

Characterization of Amphetamine, Methylphenidate, Nicotine, and Atomoxetine on Measures of Attention, Impulsive Action, and Motivation in the Rat: Implications for Translational Research(PubMed, opens in new tab)

Guy A Higgins, Leo B Silenieks, Cam MacMillan, Sandy Thevarkunnel, Anna I Parachikova, Cedric Mombereau, Hanna Lindgren, Jesper F Bastlund

Front Pharmacol. 2020 Apr 24;11:427

Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats(PubMed, opens in new tab)

Briana Renda, Allyson K Andrade, Adiia P S Stone, Rita El Azali, Michael Sharivker, Jibran Y Khokhar, Monica Antenos, Jennifer E Murray

Psychopharmacology (Berl) . 2021 Jun;238(6):1687-1701.

Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property(PubMed, opens in new tab)

Guy A. Higgins, Nicole K. Carroll, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel, Julia Izhakova, Lilia Magomedova, Ines DeLannoy, Edward M. Sellers,

Frontiers in Pharmacology, February 2021

Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research(PubMed, opens in new tab)

Amy S Fisher, Michael T Lanigan, Neil Upton, Lisa A Lione

Frontiers Pharmacology 08 February 2021

5-HT2A and 5-HT2C receptors as potential targets for the treatment of nicotine use and dependence(PubMed, opens in new tab)

Guy A Higgins, Edward M Sellers

Progress Brain Research. 2021;259:229-263.

Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank(PubMed, opens in new tab)

Michael P Vitek, Joseph A Araujo, Michael Fossel, Barry D Greenberg, Gareth R Howell, Stacey J Sukoff Rizzo, Nicholas T Seyfried, Andrea J Tenner, Paul R Territo, Manfred Windisch, Lisa J Bain, April Ross, Maria C Carrillo, Bruce T Lamb, Rebecca M Edelmayer

Alzheimers Dement (N Y). 2021 Jan 11

The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression(PubMed, opens in new tab)

Conor W McDonnell , Fionn Dunphy-Doherty, Jennifer Rouine, Massimiliano Bianchi, Neil Upton, Ewa Sokolowska, Jack A Prenderville

Frontiers Psychiatry. 2021 Jan 20;11:599588.

Human Amyloid-β 40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo(PubMed, opens in new tab)

H. Benson Peng, Keumhan Noh, Sophie R. Pan, Victor Saldivia, Sylvia Serson, Anja Toscan, Inés A.M. de Lannoy, K. Sandy Pang

Drug Metabolism & Disposition 48:944–955, October 2020

High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats (PubMed, opens in new tab)

Briana Renda, Allyson K Andrade, Jude A Frie , Cassandra L Sgarbossa , Jennifer E Murray, Jibran Y Khokhar

Drug and Alcohol Dependence. 2020 Oct 1:215:108215.

Adolescent restraint stress enhances adult nicotine reinforcement in male and female rats(PubMed, opens in new tab)

Briana Renda, Allyson K Andrade, Jude A Frie, Cassandra L Sgarbossa, Jennifer E Murray, Jibran Y Khokhar

Drug and Alcohol Dependence. 2020 Oct 1:215:108215.

Effects of 5-HT2C receptor modulation and the NA reuptake inhibitor atomoxetine in tests of compulsive and impulsive behaviour(PubMed, opens in new tab)

Guy A Higgins, Matt Brown, Jessica St John, Cam MacMillan, Leo B Silenieks, Sandy Thevarkunnel

Neuropharmacology. 2020 Jun 15;170:108064.

Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs(PubMed, opens in new tab)

Dana Vaughn, Justyna Kulpa and Lina Paulionis

Frontiers in Veterinary Science 2020 Feb 11;7:51.

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388(PubMed, opens in new tab)

Shirin Arastu-Kapur, Mai Nguyen, Debasish Raha, Florian Ermini, Ursula Haditsch, Joseph Araujo, Ines A M De Lannoy, Mark I Ryder, Stephen S Dominy, Casey Lynch, Leslie J Holsinger

Pharmacol Res Perspect. 2020 Feb;8(1):e00562.

Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential(PubMed, opens in new tab)

Guy A Higgins, Paul J Fletcher, William R Shanahan

Pharmacol Ther. 2020 Jan;205:107417.

Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial(PubMed, opens in new tab)

S Sanchis-Mora, Y M Chang, S M Abeyesinghe, A Fisher, N Upton, H A Volk , L Pelligand

Veterinary Journal. 2019 Aug;250:55-62.

Quantification of Oxysterol Nuclear Receptor Ligands by LC/MS/MS(PubMed, opens in new tab)

Lilia Magomedova, Carolyn L Cummins

Methods in Molecular Biology 2019;1951:1-14.

Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects (PubMed, opens in new tab)

Lejla Colic, Conor McDonnell, Meng Li, Marie Woelfer, Thomas Liebe, Moritz Kretzschmar, Oliver Speck, Björn H Schott, Massimiliano Bianchi, Martin Walter

Behavioural Brain Research. 2019 Feb 1;359:312-319.

Evaluation of Selective 5-HT2C Agonists in Acute Seizure Models.(PubMed, opens in new tab)

Silenieks LB, Carroll NK, Van Niekerk A, Van Niekerk E, Taylor C, Upton N, & Higgins GA.

ACS chemical neuroscience (2019).

Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction(PubMed, opens in new tab)

Mark A Seefeld, Hong Lin, Joerg Holenz, Dave Downie, Brian Donovan, Tingting Fu, Kishore Pasikanti, Wei Zhen, Matthew Cato, Khuram W Chaudhary, Pat Brady, Tania Bakshi, Dwight Morrow, Sridharan Rajagopal, Swapan Kumar Samanta, Naveena Madhyastha, Bharathi Mohan Kuppusamy, Robert W Dougherty, Ravi Bhamidipati, Zainuddin Mohd, Guy A Higgins, Mark Chapman, Céline Rouget, Philippe Lluel, Yasuji Matsuoka

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3793-3797.

Penetration and efficacy of transdermal NSAIDs in a model of acute joint inflammation(PubMed, opens in new tab)

David Charles Baranowski, Beth Buchanan, Heather C Dwyer, Joseph P Gabriele, Stephanie Kelly, Joseph A Araujo

J Pain Res. 2018 Nov 13;11:2809-2819

Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence(PubMed, opens in new tab)

Paul J Fletcher, Zhaoxia Li, Leo B Silenieks, Cam MacMillan, Ines DeLannoy, Guy A Higgins

Addiction Biology. 2019 May;24(3):376-387.

Cognitive enhancement in old dogs from dietary supplementation with a nutrient blend containing arginine, antioxidants, B vitamins and fish oil(PubMed, opens in new tab)

Yuanlong Pan, Adam D Kennedy, Thomas J Jönsson, Norton W Milgram

British Journal of Nutrition. 2018 Feb;119(3):349-358.

Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task.(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, MacMillan C, Zeeb FD, & Thevarkunnel S.

Behavioural brain research 348 (2018): 201-210.

Imepitoin shows benzodiazepine-like effects in models of anxiety(PubMed, opens in new tab)

Engel O, Masic A, Landsberg G, Brooks M, Mills DS, Rundfeldt C

Front. Pharmacol 2018

Efficacy of a therapeutic diet on dogs with signs of cognitive dysfunction syndrome (CDS): a prospective double blinded placebo controlled clinical trial(PubMed, opens in new tab)

Pan Y, Landsberg G, Mougeot I, Kelly S, Xu H, Bhatnagar S, Gardner CL, Milgram BW

Front Nutr, 2018

Studies to examine potential tolerability differences between the 5-HT2C receptor selective agonists lorcaserin and CP-809101.(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, Patrick A, De Lannoy IA, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA & Berg KA.

ACS chemical neuroscience 8.5 (2017): 1074-1084.

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus (PubMed, opens in new tab)

Marie Pereira, Stephanie Gohin, Jean-Paul Roux, Amy Fisher, Mark E Cleasby, Guillaume Mabilleau, Chantal Chenu

Frontiers in Endocrinology (Lausanne). 2017 Nov 20;8:327.

Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists(PubMed, opens in new tab)

Guy A Higgins, Fiona D Zeeb, Paul J Fletcher

J Psychopharmacol. 2017 Nov;31(11):1403-1418.

The 5‐Choice Serial Reaction Time Task.(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB.

Current protocols in pharmacology (2017): 5-49.

Effects of dietary supplementation with a mixed blueberry and grape extract on working memory in aged beagle dogs(PubMed, opens in new tab)

V Fragua, A Lepoudère, V Leray, C Baron, J A Araujo, P Nguyen, N W Milgram

Journal of Nutritional Science. 2017 Jul 12;6:e35.

Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice(PubMed, opens in new tab)

Caleb J Browne, Xiaodong Ji, Guy A Higgins, Paul J Fletcher, Colin Harvey-Lewis

Neuropsychopharmacology. 2017 Oct;42(11):2178-2187.

Development and initial validation of a sensory threshold examination protocol (STEP) for phenotyping canine pain syndromes (PubMed, opens in new tab)

Sandra Sanchis-Mora, Yu-Mei Chang, Siobhan Abeyesinghe, Amy Fisher, Holger A Volk , Ludovic Pelligand

Veterinary Anaesthesia Analgesia. 2017 May;44(3):600-614.

Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate(PubMed, opens in new tab)

Paul J Fletcher, Fiona D Zeeb, Caleb J Browne, Guy A Higgins, Ashlie D Soko

Psychopharmacology (Berl). 2017 Mar;234(5):889-902.

Young to Middle-Aged Dogs with High Amyloid-β Levels in Cerebrospinal Fluid are Impaired on Learning in Standard Cognition tests (PubMed, opens in new tab)

Herman Borghys, Bianca Van Broeck, Deborah Dhuyvetter, Tom Jacobs, Katja de Waepenaert, Tim Erkens, Melissa Brooks, Sandy Thevarkunnel, Joseph A Araujo

J Alzheimers Dis. 2017;56(2):763-774.

Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities (PubMed, opens in new tab)

David Cabañero, Takeshi Irie, Marta Celorrio, Christopher Trousdale, David M Owens, David Virley, Phillip J Albrecht, Michael J Caterina, Frank L Rice , Jose A Morón

Pain Reports. 2016 Sep;1(3):e573.

Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew)(PubMed, opens in new tab)

John A Rudd, Man P Ngan, Zengbing Lu, Guy A Higgins, Claudio Giuliano, Emanuela Lovati, Claudio Pietra

Front Pharmacol. 2016 Aug 31;7:263.

Diurnal changes in core body temperature, day/night locomotor activity patterns, and actigraphy-generated behavioral sleep in aged canines with varying levels of cognitive dysfunction(PubMed, opens in new tab)

Brian M Zanghi, Cari Gardner, Joseph Araujo , Norton W Milgram

Neurobiol Sleep Circadian Rhythms. 2016 Jul 13;1(1):8-18

Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists.(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PK, & Pratt WE.

Psychopharmacology 233.14 (2016): 2841-2856.

Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment. (PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, MacMillan C, Sevo J, Zeeb FD, & Thevarkunnel S.

Behavioural brain research 311 (2016): 1-14.

In vivo solid-phase microextraction liquid chromatography-tandem mass spectrometry for monitoring blood eicosanoids time profile after lipopolysaccharide-induced inflammation in Sprague-Dawley rats(PubMed, opens in new tab)

Vincent Bessonneau, Yanwei Zhan, Inés A M De Lannoy, Victor Saldivia, Janusz Pawliszyn

Journal of Chromatography A. 2015 Dec 11;1424:134-8.

The 5-HT(2C) receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity(PubMed, opens in new tab)

Colin Harvey-Lewis, Zhaoxia Li , Guy A Higgins, Paul J Fletcher

Neuropharmacology. 2016 Feb;101:237-45.

Dog-appeasing pheromone collars reduce sound-induced fear and anxiety in beagle dogs: a placebo-controlled study(PubMed, opens in new tab)

G M Landsberg, A Beck, A Lopez, M Deniaud, J A Araujo , N W Milgram

The Veterinary Record. 2015 Sep 12;177(10):260.

Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders(PubMed, opens in new tab)

Guy A Higgins, Paul J Fletcher

ACS Chem Neurosci. 2015 Jul 15;6(7):1071-88.

The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine(PubMed, opens in new tab)

Fiona D Zeeb, Guy A Higgins, Paul J Fletcher

ACS Chemical Neuroscience. 2015 Jul 15;6(7):1231-40.

Cognitive domains in the dog: independence of working memory from object learning, selective attention, and motor learning(PubMed, opens in new tab)

Brian M Zanghi, Joseph Araujo, Norton W Milgram

Animal Cognition. 2015 May;18(3):789-800.

Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity(PubMed, opens in new tab)

Guy A Higgins, Jill Desnoyer, Annalise Van Niekerk, Leo B Silenieks, Winnie Lau, Sandy Thevarkunnel, Julia Izhakova, Ines Am DeLannoy , Paul J Fletcher, Josepha DeLay, Howard Dobson

Pharmacol Res Perspect. 2015 Feb;3(1):e00084.

Enduring attentional deficits in rats treated with a peripheral nerve injury.(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, Van Niekerk A, Desnoyer J, Patrick A, Lau W, & Thevarkunnel S.

Behavioural brain research 286 (2015): 347-355

Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats(PubMed, opens in new tab)

Elizabeth G Guy, Daniel C Fisher, Guy A Higgins, Paul J Fletcher

Behav Pharmacol. 2014 Dec;25(8):775-83.

Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine: An Intracerebral Microdialysis Study in Conscious Rats.(PubMed Central, opens in new tab)

Durk MR, Fan J, Sun H, Yang Y, Pang H, Pang KS, de Lannoy IA.

Pharm Res. 2014 Oct 16. [Epub ahead of print]

Overview of pharmacokinetics.(PubMed Central, opens in new tab)

Aimone LD1, de Lannoy IA.

Curr Protoc Pharmacol. 2014 Sep 2;66:7.1.1-7.1.31.

Pharmacokinetics.(PubMed Central, opens in new tab)

Fan J, de Lannoy IA.

Biochem Pharmacol. 2014 Jan 1;87(1):93-120. Review.

In vivo Induction of P-Glycoprotein expression at the mouse blood-brain barrier: an Intracerebral microdialysis study.(PubMed Central, opens in new tab)

Gary N.Y. Chan, Victor Saldivia, Yingo Yang, Henrianna Pang, Inés de Lannoy, and Reina Bendayan.

Journal of Neurochemistry. 2013 Nov;127(3):342-52.

A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain(PubMed Central, opens in new tab)

Lau W, Dykstra C, Thevarkunnel S, Silenieks LB, de Lannoy IA, Lee DK, Higgins GA.

Neuropharmacology. 2013; 73: 204-215

Silexan, an essential oil from flowers of Lavandula angustifolia, is not recognized as benzodiazepine-like in rats trained to discriminate a diazepam cue(PubMed Central, opens in new tab)

Silenieks LB, Koch E, Higgins GA

Phytomedicine. 2013; 20:172-177

From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists (PubMed, opens in new tab)

Guy A Higgins, Edward M Sellers, Paul J Fletcher

Trends Pharmacol Sci. 2013 Oct;34(10):560-70.

Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles(PubMed Central, opens in new tab)

Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ.

Psychopharmacology. 2013; 226: 475-490.

Spatial reversal learning is impaired by age in pet dogs(PubMed, opens in new tab)

Paolo Mongillo , Joseph A Araujo, Elisa Pitteri, Paolo Carnier, Serena Adamelli, Lucia Regolin, Lieta Marinelli

Age (Dordr). 2013 Dec;35(6):2273-82.

Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs(PubMed, opens in new tab)

Zanghi BM, Cupp CJ, Pan Y, Tissot-Favre, DG, Milgram NW, Nagy TR, Dobson H

Am J Vet Res 2013;74:733–743

Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5HT(2A) receptor antagonist M100907 on nicotine self-administration and reinstatement.(PubMed Central, opens in new tab)

Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, Lê AD, Higgins GA.

Neuropharmacology (2012); 62(7)2288-98.

The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to effect on feeding behavior and impulse control(PubMed Central, opens in new tab)

Higgins G.A., Silenieks L.B., Roβmann A., Rizos Z., Noble K., Soko A.D., Fletcher P.J

Neuropsychopharmacology. 2012; 37: 1177-1191

Effect of age and feeding schedule on diurnal rest/activity rhythms in dogs(DOI, opens in new tab)

Brian M Zanghi, Wendell Kerr, Christina de Rivera, Joseph A Araujo, Norton W Milgram

Journal of Veterinary Behavior. 2012;7(6):339-347.

NOVIFIT (NoviSAMe) Tablets Improve Executive Function in Aged Dogs and Cats: Implications for Treatment of Cognitive Dysfunction Syndrome

Joseph A Araujo, Marjorie L Faubert, Melissa L Brooks, Gary M Landsberg, Heidi Lobprise

International Journal of Applied Research in Veterinary Medicine. 2012;10(1):90-98.

Aged dogs demonstrate both increased sensitivity to scopolamine and decreased muscarinic receptor density(PubMed Central, opens in new tab)

Araujo, J.A., Nobrega, J.N., Raymond, R., Milgram, N.W.

Pharmacology, Biochemistry and Behavior, 2011; 98(2): 203-209.

Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs(PubMed Central, opens in new tab)

Araujo, J.A., Greig, N.H., Ingram, D.K., Sandin, J., de Rivera, C., Milgram, N.W.

Journal of Alzheimer's Disease, 2011; 26(1):143-155.

Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density(PubMed, opens in new tab)

Joseph A Araujo, José N Nobrega, Roger Raymond, Norton W Milgram

Pharmacology, Biochemistry and Behavior. 2011 Apr;98(2):203-209.

Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs(PubMed, opens in new tab)

Yuanlong Pan, Brian Larson, Joseph A Araujo, Winnie Lau, Christina de Rivera, Ruben Santana, Asa Gore, Norton W Milgram

British Journal of Nutrition. 2010 Jun;103(12):1746-1754.

Serotonin receptors as potential targets for modulation of nicotine use and dependence(PubMed, opens in new tab)

Paul J Fletcher, Anh Dzung Lê, Guy A Higgins

Prog Brain Res . 2008:172:361-83

Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease(PubMed, opens in new tab)

Tiffany W Chow, Bruce G Pollock, Norton W Milgram

Neuropsychiatric Disease and Treatment. 2007;3(5):627-636.

The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues(PubMed, opens in new tab)

Paul J Fletcher, Zoë Rizos, Judy Sinyard, Maria Tampakeras, Guy A Higgins

Neuropsychopharmacology . 2008 May;33(6):1402-12

The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists(PubMed, opens in new tab)

Paul J Fletcher, Judy Sinyard, Guy A Higgins

Psychopharmacology (Berl) . 2006 Sep;187(4):515-25.

The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs(PubMed, opens in new tab)

Christa M Studzinski, Joseph A Araujo, Norton W Milgram

Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2005 Mar;29(3):489-498.

The opioid receptor like-1 receptor agonist Ro 64-6198 produces a discriminative stimulus in rats distinct from that of a mu, kappa, and delta opioid receptor agonist cue(PubMed, opens in new tab)

Matthew D Recker, Guy A Higgins

J Pharmacol Exp Ther . 2004 Nov;311(2):652-8

Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration(PubMed, opens in new tab)

Paul J Fletcher, Araba F Chintoh, Judy Sinyard, Guy A Higgins

Neuropsychopharmacology . 2004 Feb;29(2):308-18

Serotonin and drug reward: focus on 5-HT2C receptors(PubMed, opens in new tab)

Guy A Higgins, Paul J Fletcher

Eur J Pharmacol . 2003 Nov 7;480(1-3):151-62

Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging(PubMed, opens in new tab)

P Dwight Tapp, Christina T Siwak, Jimena Estrada, Elizabeth Head, Bruce A Muggenburg, Carl W Cotman, Norton W Milgram

Learning & Memory. 2003 Jan-Feb;10(1):64-73.

Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding(PubMed, opens in new tab)

Paul J Fletcher, Andrew J Grottick, Guy A Higgins

Neuropsychopharmacology . 2002 Oct;27(4):576-86

Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog(PubMed, opens in new tab)

Beth Adams, Alan Chan, Heather Callahan, Christina Siwak, Dwight Tapp, Candace Ikeda-Douglas, Patricia Atkinson, Elizabeth Head, Carl W Cotman, Norton W Milgram

Behavioural Brain Research. 2000 Feb;108(1):47-56.

5-MeO-DMT and Naltrexone Selectively Attenuate Oral Ethanol Self-administration in Male and Female Wistar Rats(poster, PDF, opens in new tab)

Briana Renda, Felipe C.K. Duarte, Jarret Folmer, Lara Mitchell, Victoria Phelps, Kevin Mills, Guy A. Higgins

RSA Research Society on Alcohol General Meeting

Effects of Three Pharmacologically Distinct Monoamine Reuptake Inhibitors on Two Measures of Compulsive Behaviour: Implications for Triple Reuptake Inhibitors(poster, PDF, opens in new tab)

Parisa Moazen, Cam McMillan, Trevor W. Robbins, Guy A. Higgins

CINP 37th World Congress of Neuropsychopharmacology

Beyond seizure control: Profiling Levetiracetam’s effect on epileptogenesis and comorbid behaviours in kindled mice(poster, PDF, opens in new tab)

Leo B. Silenieks, Annette Pisanski, Matt Brown, Lauren Stam, Anne Oakley, Maria F. Fernandes, Sandy Thevarkunnel, Uttam Das, Erika Kropf, Winthrop Gillis, John Huxter, Guy A. Higgins

American Epilepsy Society (AES)

Study of the effects of psilocybin in three rat preclinical models of migraine: insights from the trigeminovascular system(poster, PDF, opens in new tab)

Owein Guillemot-Legris, Isabelle Shand, Joshua Featherstone, Monika Baryla, Joseph Araujo, Mark Duxon, K.R. Walker, Colleen Taylor, Guy A. Higgins

SfN 2025, Nov 15th-19th

The effects of LSD and its non-hallucinogenic analogue 2-Br-LSD on murine behavior, sleep patterns, and quantitative EEG(poster, PDF, opens in new tab)

K. Marszalek, M. Domzalska, J. R. Huxter, C. Cayir, R. Ramarohetra, E. Sokolowska

SfN 2025, Nov 15th-19th

Drug effects on sleep architecture and qEEG: a cross-species comparison in mice, rats and dogs(poster, PDF, opens in new tab)

John R. Huxter, Stephanie Kelly, Anand Vardhan, Reed Percival, Ashley Bernardo, Lukasz Dlugosz, Lauren Giggins, Katarzyna Marszałek, Malgorzata Domżalska, Sandy Thevarkunnel, Ewa Sokołowska

SfN 2025, Nov 15th-19th

Phenotyping the DISC1 Rat Model of Schizophrenia using PPI, amphetamine-induced hyperlocomotion, sleep-EEG and 40Hz ASSR(poster, PDF, opens in new tab)

John Huxter, Ashley M. Bernardo, Lukasz Dlugosz, Lauren Stam, Sandy Thevarkunnel, Carsten Korth, Guy Higgins

SfN 2025, Nov 15th-19th

Characterisation of GABA2/3 positive allosteric modulators (PAMs) in tests of anxiety and side effect(poster, PDF, opens in new tab)

Guy A. Higgins, Parisa Moazen, Cam MacMillan, Karen T. Elvers, Oana Popa, John R. Atack

SfN 2025, Nov 15th-19th

Behaviour and Biomarker Changes in ARTE10 Mice Reveal Translational Potential for Alzheimer’s Disease and Mood-Related Comorbidities(poster, PDF, opens in new tab)

Ashley Bernardo, Monika Baryla, Ewa Sokolowska, Laura Griffin, Moriah Jacobson, Guy Higgins

SfN 2025, Nov 15th-19th

A Drug for All Ages: Levetiracetam Enhances Attention in Both Young and Aged Rats(poster, PDF, opens in new tab)

Parisa Moazen, Cam MacMillan, Leo B. Silenieks, Guy A. Higgins

Deconstructing OCD through the Use of Multiple Operant Behavioral Tasks in Rodents

Guy A. Higgins, PhD; Parisa Moazen, PhD; Trevor Robbins, PhD

Xtalks

Comparison of fingolimod and nod‑like receptor protein 3 inflammasome inhibitor treatment on disease progression in experimental autoimmune encephalomyelitis model(poster, PDF, opens in new tab)

A. Żochowska‑Klepańska, I. Cichoń, M. Baryła, E. Sokołowska

ECNP Congress

AI and Machine Learning Uses in Neuroscience Drug Discovery

John Huxter, PhD; Na Helian, PhD; Winthrop Gilles, PhD

Xtalks

Anxiolytic Drug Screening – Tools and Strategies for Reliable Predictions(poster, PDF, opens in new tab)

Małgorzata Potoczna, Ewa Sokołowska, Piotr Podlasz

19th International Zebrafish Conference

Advancing Psychedelic Compounds: From Preclinical Discovery to Translational Insight

Guy A. Higgins, PhD; Ewa Sokołowska, PhD; Carolyn Tyler, PhD

Xtalks

Further Characterization of a Natural Dog Model of Osteoarthritis

Anand Vardhan, Noelle McCarthy, Stephanie Kelly, Patrick Roscher, Michael Rowling, Victoria Whitehead, Constantin Trantzas, Christina de Rivera, Guy Higgins, Joseph A Araujo

Osteoarthritis Research Society International (OARSI) Conference

Pharmacokinetics (PK) of psilocybin and psilocin in plasma following intravenous administration of psilocin and oral administration of psilocybin to male beagle dogs(poster, PDF, opens in new tab)

Ines de Lannoy; Lilia Magomedova; Julia Izhakova; Christina de Rivera; James Lanthier; Jason Atkinson; Guy A. Higgins; Malik Slassi; Joseph A. Araujo [PK-psilocy...agles-2025 | PDF]

Journal of Pharmacological and Toxicological Methods

Advancing Epilepsy Research: New Strategies for Drug-Resistant Epilepsy and Associated Comorbidities

Leo Silenieks, Neil Upton, PhD; Melissa Barker-Haliski, PhD

Xtalks

Exploring the therapeutic potential of psilocybin in treatment-resistant depression: preclinical investigations in mice​(poster, PDF, opens in new tab)

Katarzyna Marszalek, Malgorzata Domżalska, Joanna Kwiatkowska, John Huxter, Ewa Sokolowska

SfN 2024, Oct. 5th-9th

Automated detection of spike-wave discharges in WAG/Rij rats: age-progression and response to chronic valproate(poster, PDF, opens in new tab)

John Huxter, Pabitra Patra, Lauren Giggins, Sandy Thevarkunnel, Guy Higgins

SfN 2024, Oct. 5th-9th

EAE Model of Multiple Sclerosis: Prophylactic Versus Treatment Fingolimod(poster, PDF, opens in new tab)

Aggelika Gana, Erwina Stojek, Dervla Moore-Frederick, Róisín Winters, Alicja Zochowska-Klepanska, Ewa Sokolowska, Ashley Bernardo, Jack Prenderville

SfN 2024, Oct. 5th-9th

Exploring the relationship between cognitive performance and gut and salivary microbial communities in Beagle dogs(poster, PDF, opens in new tab)

Andrea Cyr, Reed Percival, Noelle McCarthy, Christina de Rivera

SfN 2024, Oct. 5th-9th

Sensory Processing Deficits of MK-801 Responds to Risperidone Across ASSR-EEG, PPI and 5-CSRTT(poster, PDF, opens in new tab)

Guy Higgins, John Huxter, Lukasz Dlugosz, Cam MacMillan, Lauren Giggins, Ashley Bernardo

SfN 2024, Oct. 5th-9th

Anxiolytic‑like effect of diazepam in the novelty‑suppressed feeding and novelty‑induced hypophagia assays – exploring sex differences in C57BL/6J mice(poster, PDF, opens in new tab)

A. Żochowska‑Klepańska, A.C. McCreary, D. Virley, J. Kwiatkowska, I. Cichoń, A. Gajewska, E. Sokołowska

ECNP Congress

Changes in Neurofilament Light Levels and Gait in the Aged Beagle Dog: A natural model of osteoarthritis.

Christina de Rivera, Jack Prenderville, Patrick Roscher, Anand Vardhan, Matthew LeClaire, Roisin Winters, Michael Rowling, Victoria Whitehead, Constantin Trantzas, Joseph A Araujo

Osteoarthritis Research Society International (OARSI) Conference

Oxaliplatin-induced neuropathic pain is associated with poor sleep quality and reduced EEG alpha power in the rat(poster, PDF, opens in new tab)

Lanigan, M. T., Giggins, L., Lione, A., Duxon, M. & Kantor, S.

Neurodegeneration in the systemic rotenone model of Parkinson’s disease is associated with neuroinflammation, oxidative stress and gliosis(poster, PDF, opens in new tab)

Prenderville JA, Winters R, Lau W, Feng D, Julia Kahn, Erin McEchern, Thomas Rosahl, Daniel Zwilling, Janet Brownlees, Higgins GA.

Behaviour and biomarkers in mouse corneal kindling as a model for epilepsy, neuroinflammation and gliosis(poster, PDF, opens in new tab)

Higgins G.A, Silenieks L.B, Feng D, Brown M, Stam L, Winters R, Bastedo W, Sutton M, Oakley A, Vintuks J, Navaratnam M, Mitsogiannis M, Prenderville J.

Behaviour and sleep-EEG effects of psilocybin in the mouse, as measured with TaiNi ultra-light wireless telemetry(poster, PDF, opens in new tab)

Huxter J., Bernardo A., Carroll N., Brown M., Dlugosz L., Duxon M., Thevarkunnel S & Higgins G.

Comparison of cerebrospinal fluid biomarkers in people with mild cognitive impairment and Alzheimer's disease and the aged canine model of Alzheimer's disease(poster, PDF, opens in new tab)

Prenderville JA, Winters R, Araujo JA, De Rivera C

Evaluation of Anxiolytic Potential of Amitriptyline, Fluoxetine, and TP003 in Zebrafish Larvae Using the Light-Dark Challenge Assay(poster, PDF, opens in new tab)

Potoczna, M. Sokolowska, E. Podlasz, P.

Antidepressant efficacy of an acute administration of psilocybin and ketamine in the psychosocial stress model (CSD) – strain differences between C57BL6/J and BALB/c mice

M. DOMŻALSKA, A. PRZYBOROWSKA, E. SOKOŁOWSKA

FENS

Neurofilament Light Levels in Cerebrospinal Fluid of the Beagle Dog Increase with Age(poster, PDF, opens in new tab)

C. de Rivera, J. Prenderville, R. Winters, S. Thevarkunnel, J.A. Araujo

EEG gamma power enables robust automated sleep-staging in rodents(poster, PDF, opens in new tab)

John Huxter, Sandor Kantor, Michael Lanigan, Lauren Giggins, Leo Silenieks, Mark Duxon

SFN 2022, Nov. 12-16

Long term and delayed effects of ketamine and psilocybin in the preclinical chronic social defeat mouse model of depression(poster, PDF, opens in new tab)

M. DOMŻALSKA, J. KWIATKOWSKA, E. SOKOŁOWSKA

SFN 2022, Nov. 12-16

Psychoactive substances in the treatment of depressive disorder: Which screening test to choose?(poster, PDF, opens in new tab)

Kwiatkowska, M. Domżalska, E. Sokołowska

SFN 2022, Nov. 12-16

Acute tetrabenazine (TBZ) challenge as a translational approach to study novel antidepressants(poster, PDF, opens in new tab)

Guy A. Higgins, Leo B. Silenieks, Matt Brown, Cam MacMillan, Daniel Feng, Lilia Magomedova, Ines A.M. de Lannoy

SFN 2022, Nov. 12-16

Lipopolysaccharide (LPS) administration by intraperitoneal (i.p.) injection induces neuroinflammation and anhedonia-like behaviour in rodents(poster, PDF, opens in new tab)

F. Dunphy-Doherty, L. Davison, J. A. Prenderville

SFN 2022, Nov. 12-16

The aged dog model of Alzheimer’s Disease progression: Changes in fluid biomarkers with age and RD2, a novel AD therapeutic(poster, PDF, opens in new tab)

C. de Rivera , J. Prenderville , J. Kutzsche , D. Jurgens , L. Ashdown , K. Cross , R. Winters , D. Willbold , J. A. Araujo

SFN 2022, Nov. 12-16

Emotional and Cognitive profiling of mdx52 and mdx⁵ᶜᵛ mouse models of Duchenne muscular dystrophy(poster, PDF, opens in new tab)

M.D. Mitsogiannis, A. Aaoudi, F. Zarrouki, C. Fergus, E. Stojek, S. Talavera, V.P. Kelly, A. Goyenvalle, F. Montanaro, F. Muntoni, E. Sokolowska, C. Vaillend

SFN 2022, Nov. 12-16

Stress based models; refinement vs. translation(poster, PDF, opens in new tab)

Ewa Sokolowska, Katarzyna Marszalek

Differential effects of repeated treatment with DOI and psilocybin on the head-twitch response (HTR), locomotor activity and anxiety-like behaviour(poster, PDF, opens in new tab)

Stojek E, Dunphy-Doherty F, Prenderville J

SFN 2022, Nov. 12-16

2,5-Dimethoxy-4-iodoamphetamine (DOI) enhances motivation in low and medium but not high performers in the progressive ratio (PR) task in rats(poster, PDF, opens in new tab)

Dunfy-Doherty F, Prenderville J

SFN 2022, Nov. 12-16

Gender differences in pre-clinical models of Chemotherapy Induced Neuropathy(poster, PPTX, opens in new tab)

Daniel W Cohn

Development of a high-throughput translational platform for preclinical screening substances with potential therapeutic effect in disorders of the central nervous system. June 2022(poster, JPG, opens in new tab)

Malgorzata M, Sokolowska E and Podlasz P

Assessing the immunogenicity of alpha-synuclein, oligomers, filaments and fibrils in a clinically relevant model of synucleinopathy in vitro.(poster, PDF, opens in new tab)

Caoimhe Tyndall, D. Lobo, D.A. Kozareva, J. Prenderville, Vicky Myhre, A. Louwrier, A. Harkin

AD/PD 2022 March 15-20

Rapid acting antidepressants in motivation: the effect of psychedelic drugs in the rat progressive ratio task - SfN 2021(Abstract, opens in new tab)

F. DUNPHY-DOHERTY, D. KOZAREVA, J. R. KELLY, J. PRENDERVILLE

Society for Neuroscience 2021

Behavioural comparison of the UVB model of sterile inflammatory pain between Wistar rats and C57BL/J mice(Abstract, opens in new tab)

A David-Pereira, C. Millum, C. Taylor

SFN 2021 Nov. 8-11

Novel Pharmacologic Approaches in Neuropathic Pain Therapy. SMI 2021(Abstract, opens in new tab)

Daniel Cohn

SMI 2021

Psilocybin selectively suppresses REM sleep in the Wistar Kyoto rat model of treatment-resistant depression(Abstract, opens in new tab)

Kantor S, Giggins L, Upton N, Duxon M

Society for Neuroscience 2021

Characterisation of Behavioural, Safety and Pharmacokinetics (PK) Properties of Psilocybin and Psilocin in Rodents(Abstract, opens in new tab)

G.A. Higgins, N. Carroll, M. Brown, C. MacMillan, A. Toscan, J.A. Araujo, M. Slassi, C. Cassidy, R. Ramarohetra, C. Taylor, L. Magomedova, I.A.M. de Lannoy

SFN 2021 Nov 8-11

Efficacy of low doses of neuroleptic drugs on aggressive behaviour and corticosterone levels in CD 1 male mice(Abstract, opens in new tab)

Sokołowska E, Stojek E, Kozareva DA, Prenderville JA

SFN 2021 Nov. 8-11

Optimized 40Hz ASSR in rodent cortical EEG - validation using a ketamine model of NMDA receptor hypofunction(Abstract, opens in new tab)

J. R. Huxter, S. Kantor, L. Giggins, M. Duxon

SFN 2021 Nov. 8-11

Thermal nociception in large Theraphosid spiders using the plantar Hargreaves test apparatus - SfN 2021(Abstract, opens in new tab)

A. UPTON, B. KENNEDY, D. COHN, C. TAYLOR, S. BAKER, C. TRIM, S. TRIM

Society for Neuroscience 2021

Enhanced fear- and anxiety-related behaviours and impaired fear learning in mdx52 and mdx5cv mouse models of Duchenne muscular dystrophy(Abstract, opens in new tab)

M. D. MITSOGIANNIS, A. SAOUDI, F. ZARROUKI, C. FERGUS, E. STOJEK, S. TALAVERA, V. P. KELLY, A. GOYENVALLE, F. MONTANARO, F. MUNTONI, E. SOKOLOWSKA, C. VAILLEND

SFN 2021 Nov 8-11

Evaluation of Human ex vivo and Rodent in vivo Models of Inflammation for CNS Anti-Inflammatory Drug Development(poster, PDF, opens in new tab)

L.R. Davison, D. Kozareva, F. Dunphy-Doherty, J.A. Prenderville

NIDDF Conference 2021

Advancing preclinical models to accelerate the discovery of novel psychedelic therapeutics(poster, PDF, opens in new tab)

Prenderville J

Neuroscience Ireland 2021

Glial-Neuronal Interaction Prompted by Recombinant Fibrillar Protein Constructs of Alpha-Synuclein –an in vitro Characterisation(poster, PDF, opens in new tab)

C. Tyndall, T. Burke, D. Kozareva, J. Prenderville, E. Sokolowska, A. Netter-Glangeaud, A. Louwrier, A. Harkin

AD/PD 2021 March 9-14

The effect of the second generation of antipsychotic risperidone on aggressive behaviour in male CD-1 mice(poster, PDF, opens in new tab)

SOKOLOWSKA E, STOJEK E, KOZAREVA DA, PRENDERVILLE J

FENS Regional Meeting 25-27 August 2021

Establishment of a human whole blood NLRP3 inflammasome activation assay for evaluating novel inhibitors: assessment of cannabidiol. Luke Davison with voiceover in english.(poster, PDF, opens in new tab)

Davison L.R., Prenderville J.A.

Assessment of Once Daily Dosing with ProZinc® Insulin in Diabetic Beagle Dogs(poster, PDF, opens in new tab)

Cynthia R. Ward VMD PhD, Martha Winhall DVM, Carla Kroh DVM, Walt Ingwersen DVM, Philip Watson BVetMed

Poster presented at ACVIM meeting, 2021

Femoral Fracture in a Mouse Model Induces Evoked and Naturalistic Pain Behaviours(poster, PDF, opens in new tab)

Ran Magnusdottir, Stephanie Gohin, Amy Fisher, Neil Upton, Chantal Chenu

Translational endpoints for preclinical pain(Abstract, opens in new tab)

Pereira A

SMi Pain Therapeutics 2021 May 10-11

Pitfalls and prospects in cognitive assays in preclinical research(poster, PDF, opens in new tab)

Huxter J

A53T alpha-synuclein promotes a rapid neurodegeneration and motor deficit following AAV vector mediated expression in the rat substantia nigra(poster, PDF, opens in new tab)

Burke T, Ryan L, Prenderville J, Sokolowska E, Kozareva D, Upton N and Harkin A

AD/PD 2021 March 9-14

Behavioural assessment of acute and a long-term antidepressant and anxiolytic efficacy in mice(poster, PDF, opens in new tab)

Sokolowska E

Neuronus 2020

21st International Conference on AD Drug Discovery - Luke Davison

Davison L

Chronic social defeat mouse model in pursuit of biomarkers for depression(Abstract, opens in new tab)

Sokolowska E, Burke T, Dunphy-Doherty F, Kozareva D and Stojek E

33rd ECNP Congress 12-15 Sept 2022

Further investigation into the translational utility of Oxaliplatin induced behavioural models

Investigation of the plasma cytokine/chemokine profile of the chronic constriction injury rat model of neuropathic pain: relevance to pharmacological reversal of allodynia(poster, PDF, opens in new tab)

SOKOLOWSKA E, PRENDERVILLE JA, BIANCHI M, THOMAS AL, FISHER AS, UPTON N

The streptozocin model of diabetes, induces neuropathic pain and changes in quality of life measures which can be modulated by social interaction/welfare(poster, PDF, opens in new tab)

A. Fisher, M. Burnett, P. Kennard, L. Lione, N. Upton

Eminent Increase in EEG Gamma Oscillation in the Wistar Kyoto Rat Model of Treatment-Resistant Depression After Ketamine Treatment(poster, PDF, opens in new tab)

S. Kantor, M. Duxon, N. Upton

The NMDAr positive allosteric modulator CAD-8688 reverses mismatch negativity impairments in the rat sub-chronic PCP model of schizophrenia(poster, PDF, opens in new tab)

S. Kantor, S.C. Leiser, D. Anderson, R. Volkmann, N. Upton, T.Piser

Webinar 1: KETAMINE; TRAILBLAZER AND STILL RELEVANT PLAYER(Abstract, opens in new tab)

F. DUNPHY-DOHERTY

Webinar 2: PSYCHEDELICS; PRECLINICAL TRIALS AND TRANSLATABILITY(Abstract, opens in new tab)

F. DUNPHY-DOHERTY

Webinar 3: PSYCHEDELICS; IN THE CLINIC, FUTURE DIRECTIONS(Abstract, opens in new tab)

F. DUNPHY-DOHERTY

Investigation of the temporal plasma cytokine/chemokine profile of the monosodium iodoacetate rat model of osteoarthritis: relevance to pharmacological reversal of hyperalgesia(poster, PDF, opens in new tab)

J. A. PRENDERVILLE, E. SOKOLOWSKA, M. BIANCHI, A.L. THOMAS, C. MONTAGUT-BORDAS, A.S. FISHER, N. UPTON, A.H. DICKENSON

Investigation of lipopolysaccharide (LPS) administration by intraperitoneal (i.p.) injection and intracerebroventricular (i.c.v) infusion as mouse models of neuroinflammation(poster, PDF, opens in new tab)

Davison LR, Zwilling D, Wolfe H, Willis R, Hafey MJ, Xiong T, Stojek E, Mitsogiannis M, Bogen S, Brownlees J, Prenderville J

The NMDA Receptor Antagonist Ketamine Exerts Biphasic Effects on Mismatch Negativity in the Rat(poster, PDF, opens in new tab)

S. Kantor, B. Laursen, N. Upton, J. F. Bastlund

A novel tau transgenic mouse model overexpressing human tau and an aggregation-prone tau sequence shows tau hyperphosphorylation and behavioral deficits in the Morris Water Maze.(Abstract, opens in new tab)

Rosahl TW, Varty GB, Smith SM, Gentzel R, Carroll N, Silenieks L, Higgins GA, Schachter J.

Society for Neuroscience meeting, Chicago, October 19-23 2019

Effect of lorcaserin and atomoxetine in two tests of compulsive action.(Abstract, opens in new tab)

Higgins GA, Brown M, MacMillan C, Silenieks LB.

Society for Neuroscience meeting, Chicago, October 19-23 2019

Effect of acute and chronic antidepressant treatment on the Wistar Kyoto in forced swim test and on corticosterone expression(poster, PDF, opens in new tab)

McDonnell CW, Gill M, Upton N, Bianchi M

European College of Neuropsychopharmacology 2019 Meeting

Development and validation of a dog travel anxiety model

Landsberg G, Mougeot I, Kosziwka W et al.

In Proc 12th International Veterinary Behaviour Meeting. Washington, D.C. IVBM, Upton, UK. 2019; 21-23

Anxiolytic effect of dexmedetomidine oromucosal gel (Sileo) and gabapentin in a feline travel anxiety model

Landsberg G, Dunn D, Korpivaara M

In Proc 12th International Veterinary Behaviour Meeting. Washington, D.C. IVBM, Upton, UK. 2019; 94-95

Pharmacological and Cross Validation of a Translational Pain Questionnaire Assessing Behavioral Quality of Life Measures Across Acute Urate-Induced Pain in dogs and a Naturalistic Canine Model of Osteoarthritic Pain(poster, PDF, opens in new tab)

J.A. Araujo and M.J. Winhall

Intervivo Solutions

Altered Inflammatory signaling in Cerebrospinal Fluid (CSF) of Mild Cognitive Impairment (MCI) versus Alzheimer’s disease (AD) Analysis of cytokines/chemokines, Amyloid Beta and Tau(Abstract, opens in new tab)

J.A. Prenderville, T. Burke, C.W. McDonnell, M. Bianchi

Society for Neuroscience 2018 Nov. 3-7

Supplementation with a novel lipid extract improves frontal lobe linked cognitive deficits in an aged beagle model of Alzheimer’s disease(poster, PDF, opens in new tab)

Joseph A Araujo, Sergi Segarra, Andrea Paradis, Sandy Thevarkunnel and Norton W Milgram

Alzheimer’s Association International Conference, July 22-26, 2018, Chicago, USA

Assessing stress in laboratory dogs to car rides and rehousing

Landsberg GM, Araujo JA, Fish J, Thevarkunnel S

Abstract: Proc 1st ECVBMAW, Berlin, 2018, 367-269

Mismatch Negativity in rats –A translational model in schizophrenia research(Abstract, opens in new tab)

Neil Upton, Graham Wadsworth, Dave R. Anderson, Timothy Piser, Steven C. Leiser

SFN 2017 Washington DC Nov 11-15 2017

Ketoconazole inhibition of midazolam metabolism to 1’OH-midazolam in the chimeric mouse with humanized liver and the SCID mouse(poster, PDF, opens in new tab)

Inés de Lannoy¹, Masakazu Kakuni², Sophie Pan¹, Julia Izhakova¹, Alexander Kitayev² and Yoshio Morikawa²

Intervivo Solutions, Canada and PhoenixBio, Japan

Cortisol content in hair measured by liquid gas chromatography-tandem mass spectrometry; a non-invasive marker of chronic stress in companion animals

Mougeot I, Fish J, De Lannoy I, Grujic A, Landsberg G

In: Denenberg S. (ed) Proc 11th International Veterinary Behaviour Meeting. Oxfordshire: CABI 2017, 108-109

The effects of a nutritional supplement (Solliquin) in reducing fear and anxiety in a laboratory model of thunder induced fear and anxiety

Landsberg G, Huggins S, Fish J et al.

In Denenberg S (ed). Proc 11th International Veterinary Behaviour Meeting, CABI: Oxfordshire, 2017; 94-97

A longitudinal study of PINK1 and PARK7 KO rats(Abstract, opens in new tab)

N.W. Milgram,. J.A. Caskanette, A. Van Niekerk, A. Patrick, L.B. Silenieks, W. Lau, S. Thevarkunnel, J.A. Araujo, G.A. Higgins

Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

Validation of a translational pain questionnaire assessing behavioral quality of life measures in a naturalistic canine model of osteoarthritic pain and urate-induced pain(Abstract, opens in new tab)

J. A. Araujo , S. Kelly , J. Baulk , D. Araujo , C. De Rivera , D. Baronowski , J. Gabriele

Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

Characterisation of two NMDA NR2B subunit (grin2b) antagonists across tests of impulsivity and attention(Abstract, opens in new tab)

G. A. Higgins , L. B. Silenieks , C. MacMillan , J. Sevo , F. D. Zeeb , S. Thevarkunnel

Society for Neuroscience meeting, San Diego, November 12–16 2016, poster

A study of the selective 5-HT2C agonists Lorcaserin and CP-809101 on side-effect profile, CNS penetration and functional selectivity.(Abstract, opens in new tab)

Higgins GA, Silenieks LB, Patrick A, DeLannoy IAM, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA.

Poster presented at SFN 2015 meeting in Chicago

A study of selective 5-HT2C agonists Lorcaserin and CP-809101 on measures of impulsivity and food reinstatement in the rat.(poster, PDF, opens in new tab)

Higgins GA, Silenieks LB, Altherr EB, Patrick A, MacMillan C, DeLannoy IAM, Fletcher PJ, Pratt WE.

EBPS meeting 2015 in Verona, Italy

Evaluation of synthetic derivatives of medium chain triglyceride (mct) fatty acids in mice(Abstract, opens in new tab)

J.A. Araujo, J. Caskanette, A. Patrick, W. Lau, B. Milgram, J. Bautista, L. Balenci, J.S. Andrews, S. Annedi, 1, G.A. Higgins

SFN2015 meeting, October 17-21. Chicago

A backtranslational study of the selective 5-HT2C agonist lorcaserin in two rat obesity models(Abstract, opens in new tab)

Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Delay J, Dobson H.

Society for Neuroscience meeting, San Diego, Nov 9-13th 2013.

Evaluation of the Zucker fatty rat as a model of diabetic neuropathy(Abstract, opens in new tab)

Higgins GA, Lau W, Desnoyer J, DeLannoy IAM, Milgram NW

Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

The reliability and effects of age on CSF measures of b-Amyloid and tau in beagle dogs; implications for a natural animal model of Alzheimer's disease progression(Abstract, opens in new tab)

C. de Rivera, B. Chakravarthy, S. Kelly, J. Baulk, M.L. Brooks, B. Milgram, J.A. Araujo

Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

Aged Beagle Dogs Demonstrate Reduced Brain Metabolism Measured By FDG-PET-MR(Abstract, opens in new tab)

Joseph A Araujo, Kate Sokolnicki, Jacob Hesterman, Jack Hoppin, Dale E. Araujo, Howard Dobson

Society for Neuroscience meeting, San Diego Nov 9-13th 2013.

Characterization of the highly selective 5-HT2C receptor agonists lorcaserin and CP-809101 on food and nicotine motivated behaviors in the rat(Abstract, opens in new tab)

Higgins GA, Silenieks LB, Lau W, De Lannoy IAM, Lee DKH, Le AD, Fletcher PJ

Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

Characterisation of acute and chronic administration of pregabalin (Lyrica®) on multiple endpoints in the rat spared nerve injury model.(Abstract, opens in new tab)

Higgins GA, Lau W, Dykstra C, Silenieks LB, De Lannoy IAM, Lee DKH, Pang HY, Araujo JA

Society for Neuroscience meeting, New Orleans, Oct 13-17th 2012, Poster

Characterisation of Pregabalin (Lyrica ®) on multiple behavioural endpoints in the rat spared nerve injury model(poster, PDF, opens in new tab)

Winnie Lau, Crystal Dykstra, Leo B. Silenieks, Mogjan Mohagheghi, Sandy Thevarkunnel, Ines A.M. de Lannoy, David K.H. Lee, Joseph Araujo, Guy A. Higgins

IASP meeting, Milan, Italy, August 27-30th 2012; poster PT222

Evaluation of translational disease biomarkers in the aged dog; The effects of age and BACE inhibition on CSF amyloid(poster, PDF, opens in new tab)

Joseph A. Araujo, Guy A. Higgins, Christina de Rivera, Norton W. Milgram

Alzheimer's Association International Conference, 2011

Examination of the 5-HT2C receptor agonists lorcaserin and Ro 60-0175 against nicotine discrimination and dependence in the rat(Abstract, opens in new tab)

Guy Higgins, Leo B. Silenieks, Winnie Lau, Paul J. Fletcher

Society for Neuroscience meeting, Washington, D.C., November 12-16th 2011, poster

The selective 5-HT2C receptor agonist, lorcaserin, reduces indices of nicotine reward as well as food intake in the rat(Abstract, opens in new tab)

Guy A. Higgins, Leo Silenieks, Zoe Rizos, Kevin Noble, Paul J. Fletcher

Society for Neuroscience meeting, San Diego, November 13-17th 2010

Characterisation of the 5-HT6 receptor antagonist, SB-742457, on cognitive test performance in the rat(Abstract, opens in new tab)

Guy A. Higgins, Leo Silenieks, Winnie Lau, Sandy Thevarkunnel, Alan Henderson, Nicholas Moore

Society for Neuroscience meeting, San Diego, November 13-17th 2010