Safety studies provide a behavioural profile of a novel compound and compare it to that of a known drug of abuse. Efficacy studies test the ability of a novel compound to alter the behavioural effects of a known drug of abuse.
Assay: Functional Observational Battery test
Data presented: Nicotine dose-dependently increases locomotor activity in male Sprague-Dawley rats.Data presented: Elevated locomotor activity elicited by nicotine (0.2 mg/kg, SC) can be blocked by administering the smoking cessation therapy, Varenicline (α4β2 receptor partial agonist), 30 min prior to nicotine administration (n=8 male Sprague-Dawley rats).
