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Models & Assays

Disease Model EfficacyPK & SafetyAged Beagle Model

Pathology

  • Aged Dogs Exhibit Both Early Amyloid-Aβ and Tau Pathologies

Drug Screening

  • Aβ Antibody Strategies
  • BACE Inhibitors
  • Comparative Drug Screening

Imaging

  • Cancer Imaging
  • Functional Brain Imaging
  • Image Processing
  • Interventional Imaging
  • Magnetic Resonance Spectroscopy
  • Musculoskeletal Imaging
  • Quantitative Magnetic Resonance
  • Specific Organ Imaging
  • Structural Brain Imaging
  • Whole Body Imaging

Comparative Drug Screening

The effects of putative AD therapeutics on CSF biomarkers in aged dogs provides a rapid screen in a higher mammalian model that naturally develops AD-like pathology. We have experience in conducting relatively rapid screens for studying the effect of multiple NCEs on CSF biomarkers to support the lead optimization process which can be followed up with more extensive studies on selected compounds.

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  • Alzheimer's Disease
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  • CNS Drug Disposition
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  • Depression/Anxiety
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  • Essential Tremor
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  • Inflammation
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  • Multiple Sclerosis
  • Neuropathic Pain
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  • Parkinson's Disease
  • PK/PD Studies
  • PK-Bridge
  • Psychedelics
  • PXB Mouse Studies
  • Safety Studies
  • Schizophrenia
  • Veterinary Research
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