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Models & Assays

Disease Model EfficacyPK & SafetyAged Beagle Model

Pathology

  • Aged Dogs Exhibit Both Early Amyloid-Aβ and Tau Pathologies

Drug Screening

  • Aβ Antibody Strategies
  • BACE Inhibitors
  • Comparative Drug Screening

Imaging

  • Cancer Imaging
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  • Image Processing
  • Interventional Imaging
  • Magnetic Resonance Spectroscopy
  • Musculoskeletal Imaging
  • Quantitative Magnetic Resonance
  • Specific Organ Imaging
  • Structural Brain Imaging
  • Whole Body Imaging

Musculoskeletal Imaging

Depending on the research question to be answered several different imaging modalities can be used in musculoskeletal imaging. Magnetic Resonance Imaging provides images of the greatest range of tissues including bone marrow and changes in the internal structure of a joint, including articular cartilage changes, whereas CT can provide detailed images of bone structure.

Our range of magnets available allows MR imaging of beagles at up to 9.4T. Plain radiographs can illustrate basic morphometric changes with either contrast radiography or ultrasound adding details of the internal structure of joints. Nuclear medicine studies provide quantitative information on bone metabolic turnover and studies can be focused on a specific area or can include the entire skeletal system.

Dog knee radiograph

From left to right: Radiograph of a dog knee with osteoarthritis; MR image of a normal dog knee.

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