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Models & Assays

Disease Model EfficacyPK & SafetyAged Beagle Model

Pathology

  • Aged Dogs Exhibit Both Early Amyloid-Aβ and Tau Pathologies

Drug Screening

  • Aβ Antibody Strategies
  • BACE Inhibitors
  • Comparative Drug Screening

Imaging

  • Cancer Imaging
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  • Magnetic Resonance Spectroscopy
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  • Quantitative Magnetic Resonance
  • Specific Organ Imaging
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Magnetic Resonance Spectroscopy

Chemical shift graph
Quantification of changes in brain chemistry associated with the development and decline of neural function in response to therapeutics
MRS concentration bar chart
Magnetic resonance spectroscopy data showing changes in brain metabolites associated with brain development in growing beagles, including markers of neuronal health. Effects of therapeutics can be assessed in attenuating or improving brain development
Percent change chart across metabolites
Data showing change in concentration of brain metabolites in 10 year old compared to 2 year old beagle dogs

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